Structure and properties of two component hydrogels comprising lithocholic acid and organic amines

Pal, Asish; Basit, Hajra; Sen, Saikat; Aswal, Vinod K.; Bhattacharya, Santanu

doi:10.1039/b903407b

Cited by 120 publications

(95 citation statements)

References 72 publications

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“…While there have been reports about lithocholic acid (LCA) derivative-based gels in the literature [23,24,92], a larger portion of research has been directed towards derivatives of deoxycholic acid (DCA) and cholic acid (CA) [21,22,[25][26][27]31,[34][35][36][37][38]. A common opinion about LCA derivatives (with only a single OH group attached to the steroidal skeleton) as gelators is that their ability to form the necessary hydrogen-bonding network to induce gelation is poor compared to DCA, CDCA (chenodeoxycholic acid), or CA derivatives, which contain two or three OH-groups in their framework [24,27].…”

Section: Discussionmentioning

confidence: 99%

Bile acid alkylamide derivatives as low molecular weight organogelators: Systematic gelation studies and qualitative structural analysis of the systems

Löfman

Koivukorpi

Noponen

et al. 2011

Journal of Colloid and Interface Science

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Section: Discussionmentioning

confidence: 99%

Bile acid alkylamide derivatives as low molecular weight organogelators: Systematic gelation studies and qualitative structural analysis of the systems

Löfman

Koivukorpi

Noponen

et al. 2011

Journal of Colloid and Interface Science

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“…Synergistic behavior is observed in case of the composite gel of 1, containing a mixture of EG and SWNT, when compared with otherCertain organic molecules, known as low-molecular-mass organogelators, (LMMGs), [22] self-assemble through weak intermolecular interactions, such as hydrogen bonding, p-p stacking, and van der Waals forces, leading to gelation of specific solvents. [23] Gelation takes place through entrapment and immobilization of solvent molecules into entangled 3D networks. The organization and properties of such gels can be modulated by the incorporation of nanoparticles or -tubes.…”

Section: Introductionmentioning

confidence: 99%

Composites of Graphene and Other Nanocarbons with Organogelators Assembled through Supramolecular Interactions

Samanta

Subrahmanyam

Bhattacharya

et al. 2012

Chemistry A European J

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Carbon nanomaterials (CNMs), such as exfoliated graphene (EG), long-chain functionalized EG, single-walled carbon nanotubes (SWNTs), and fullerene (C(60)), have been investigated for their interaction with two structurally different gelators based on all-trans tri-p-phenylenevinylene bis-aldoxime (1) and n-lauroyl-L-alanine (2) both in solution and in supramolecular organogels. Gelation occurs in toluene through hydrogen bonding and van der Waals interactions for 1 and 2 in addition to π-π stacking specifically in the case of 1. These nanocomposites provide a thorough understanding in terms of molecular-level interactions of dimensionally different CNMs with structurally different gelators. The presence of densely wrapped CNMs encapsulated fibrous network in the resulting composites is evident from various spectroscopic and microscopic studies, indicating the presence of supramolecular interactions. Concentration- and temperature-dependent UV/Vis and fluorescence spectra show that CNMs promote aggregation of the gelator molecules, leading to hypochromism and quenching of the fluorescence intensity. Thermotropic mesophases of 1 are altered by the inclusion of a small amount of CNMs. The gel-CNM composites show increased electrical conductivity compared with that of the native organogel. Rheological studies of the composites demonstrate the formation of rigid and viscoelastic solidlike assembly due to reinforced aggregation of the gelators on CNMs. Synergistic behavior is observed in case of the composite gel of 1, containing a mixture of EG and SWNT, when compared with other mixtures of CNMs in all combinations with EG. This affords new nanocomposites with interesting optical, thermal, electrical, and mechanical properties.

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“…Bhattacharya et al reported two-component hydrogels of bile acids (such as lithocholic acid) and various amines (such as 1,2-ethanediamine) at a total concentration of 5.0 wt %. 48 The authors dissolved the mixture by sonicating at 60–70 °C, then cooled gradually to the room temperature to get the heterotypic hydrogels. It is common and effective for generating hydrogels by combining ultrasound and temperature change.…”

Section: Methods For Hydrogelationmentioning

confidence: 99%

“…While each component of the heterotypic hydrogels by itself is unable to form hydrogels due to insufficient intermolecular interactions in water, the combination of different components results in new complexes via adequate non-covalent interactions. Generally, more than one type of physical interactions coexist between the different hydrogelators, such as the presence of hydrogen bonding and hydrophobic interactions, 31–33, 37, 40–47 or the coexistence of hydrogen bonding and electrostatic interactions, 48–51 or the presence of hydrogen bonding, hydrophobic interactions, and electrostatic interactions. 52, 53 In general, more stable hydrogels form when multiple kinds of non-covalent interactions enhance each other in water.…”

Section: Driving Forcementioning

confidence: 99%

Heterotypic supramolecular hydrogels

Yuan

2016

J. Mater. Chem. B

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Supramolecular hydrogels, formed via intermolecular interactions in water, are emerging as a new type of versatile soft materials to be applied in many areas, such as biomedical applications, catalysis, food additives, and cosmetics. While most of the supramolecular hydrogels are homotypic (i.e., one type of building blocks), heterotypic supramolecular hydrogels are less explored, but may offer unique advantages. This review discribes supramolecular hydrogels that consist of more than one type building blocks (i.e., heterotypic) to illustrate the promises and challenges of heterotypic supramolecular hydrogels as soft biomaterials. First, we discuss the driving force for producing heterotypic supramolecular hydrogels. Second, we introduce the general methods for triggering heterotypic supramolecular hydrogels. Third, we summarize the examples of heterotypic supramolecular hydrogels made of hydrogelators with or without containing amino acid residues. Fourth, we describe the applications of heterotypic supramolecular hydrogels up-to-date. Finally, we give the outlook and propose a few future directions that likely worth to be explored.

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Structure and properties of two component hydrogels comprising lithocholic acid and organic amines

Cited by 120 publications

References 72 publications

Bile acid alkylamide derivatives as low molecular weight organogelators: Systematic gelation studies and qualitative structural analysis of the systems

Bile acid alkylamide derivatives as low molecular weight organogelators: Systematic gelation studies and qualitative structural analysis of the systems

Composites of Graphene and Other Nanocarbons with Organogelators Assembled through Supramolecular Interactions

Heterotypic supramolecular hydrogels

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