Structure and Role of Langerhans’ Cells in the Human Oesophageal Epithelium

Terris, Benoı̂t; Potet, F

doi:10.1159/000201295

Cited by 22 publications

(18 citation statements)

References 30 publications

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“…Lymphocytes do not show a particular distribution and are scattered throughout the squamous epithelium. These findings support a growing body of literature that is defining the immunologic milieu of the esophageal mucosa and suggests that the esophagus may participate in an immune response to swallowed solids and liquids [14][15][16].…”

Section: Is Eosinophilic Esophagitis An Allergic Disease?supporting

confidence: 80%

Eosinophilic esophagitis: An emerging clinicopathologic entity

Furuta

2002

Curr Allergy Asthma Rep

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Eosinophilic esophagitis is a clinicopathologic disease characterized by 1) persistent upper intestinal symptoms despite the patient's use of gastric acid blockade and 2) large numbers of eosinophils in the squamous epithelium of the esophagus. This disease is increasing in frequency and the exact etiologic agent(s) remain elusive. The major importance of identifying eosinophilic esophagitis is that affected patients are receiving fundoplication for persistent symptoms when, in fact, corticosteroids or diet restriction is the treatment of choice.

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Section: Is Eosinophilic Esophagitis An Allergic Disease?supporting

confidence: 80%

Eosinophilic esophagitis: An emerging clinicopathologic entity

Furuta

2002

Curr Allergy Asthma Rep

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“…The presence of LCs in the human esophageal epithelium, of the stratified squamous type, was reported previously (Geboes et al, 1983;Terris and Potet, 1995). Moreover, a positive correlation has been reported to exist between the number of LCs in the esophageal epithelium and certain pathologies, such as human papilloma virus infection, squamous dysplasia, and invasive carcinoma (Morris and Price, 1986;Matsuda et al, 1990).…”

mentioning

confidence: 77%

Variation in Langerhans cell number and morphology between the upper and lower regions of the human esophageal epithelium

et al. 2002

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Langerhans cells (LCs) are dendritic components of stratified epithelia, presenting antigens to other cells of the immune system that play a crucial role in local defense. The paucity of information about their significance in the esophageal mucosa was addressed by studying their distribution and morphology in this particular location. LCs were identified by immunohistochemical detection of CD1a, a cell-specific marker, using a monoclonal antibody, as well as by electron microscopic identification of characteristic Birbeck granules, among other typical morphological features. Cell counts carried out at 25 and 35 cm distal to the dental arch demonstrated significant differences in number and size between the two locations. The upper region contained 10.4 Ϯ 0.8 cells (mean Ϯ SEM) vs. 18.4 Ϯ 1.4 cells in the lower region. Also, cells in the lower region were larger and appeared to have longer dendritic processes. To our knowledge this is the first report of regional differences in number and morphology of LCs in human esophageal mucosa. Anat Rec 268: 360 -364, 2002.

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“…The structure, distribution, and function of DCs existing in the esophageal tissues DCs existing in the esophageal tissues belong to Langerhans cells (LCs); they are bone marrow-derived dendritic cells [14][15][16][17][18]. In addition to possessing membrane receptors for the Fc fragment of IgG and complement fractions such as C3b [19], they also express the surface antigens CD1a and human leukocyte antigen (HLA)-DR, which can be identified by means of specific monoclonal antibodies.…”

Section: The Function Origin and Differentiation Of Dcsmentioning

confidence: 99%

“…Associated with relatively numerous intra-epithelial lymphocytes present in the normal state in esophageal mucosa, they play a major role in the immunologic defense system of the esophagus [24,25]. They can efficiently take up and process a wide variety of antigens, including contact sensitizers, tumor-associated antigens, and microbial antigens [26,27].…”

Section: The Function Origin and Differentiation Of Dcsmentioning

confidence: 99%

Immunologic Function of Dendritic Cells in Esophageal Cancer

Yang

2007

Dig Dis Sci

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Esophageal cancer is one of the frequently occurring malignant cancers. The current therapy, including surgery, chemotherapy, radiotherapy, or a combination, is only to palliate the symptoms; overall the prognosis is poor. The immunotherapy of dendritic cells for esophageal cancer is a valuable method. Dendritic cells existing in the esophageal tissues play an important role in the host's immunosurveillance against cancer as the professional antigen-presenting cells. This review concerns the immunology of dendritic cells in esophageal cancer; it describes the expression of DCs in the normal esophageal tissues and benign disease of esophagus, relations between the DCs and cancer development in esophageal cancer, and the DC-based approach to establish treatment for esophageal cancer.

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Structure and Role of Langerhans’ Cells in the Human Oesophageal Epithelium

Cited by 22 publications

References 30 publications

Eosinophilic esophagitis: An emerging clinicopathologic entity

Eosinophilic esophagitis: An emerging clinicopathologic entity

Variation in Langerhans cell number and morphology between the upper and lower regions of the human esophageal epithelium

Immunologic Function of Dendritic Cells in Esophageal Cancer

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