Structure and urease inhibitory activity of copper(II) complex with (E)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylic acid

Chen, X.-F.; Wang, C.-F.; Kong, Shiao‐Tong; Li, C.; Zhou, Xiaoshuang; Zhang, C.-Y.; Sheng, Guangyao; Zhu, Hai‐Liang

doi:10.1134/s0022476617040229

Cited by 9 publications

(3 citation statements)

References 29 publications

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“…Quite complex structure is a ternary chelate composed of two copper (II) ions with four molecules of (( E )-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylic acid (simple derivative of cinnamic acid) and two molecules of DMSO. It is potent, submicromolar inhibitor of jack bean urease [109] .…”

Section: Coordination Complexesmentioning

confidence: 99%

Recent advances in design of new urease inhibitors: A review

Kafarski

Talma

2018

Journal of Advanced Research

193

111

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Section: Coordination Complexesmentioning

confidence: 99%

Recent advances in design of new urease inhibitors: A review

Kafarski

Talma

2018

Journal of Advanced Research

193

111

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“…Urease activity is a prominent pathogen in the pathogenesis of many clinical conditions such as ulcers and some stomach disorders. Helicobaster pylori survives by using the urease enzyme [13–14] . Tyrosinase activity plays a key role in melanogenesis and accumulation of melaning pigments may be linked with skin disorders.…”

Section: Introductionmentioning

confidence: 99%

Turanecio hypochionaeus: Determination of Its Polyphenol Contents, and Bioactivities Potential Assisted with in Silico Studies

Kısa

İmamoğlu

Kaya

et al. 2022

Chemistry & Biodiversity

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The aim of this study was to identify and quantify the phenolic composition of Turanecio hypochionaeus Bosse and determine the anti-urease, anti-lipase, antidiabetic, anti-melanogenesis, antibacterial, and anti-Alzheimer properties. IC 50 results for all enzymes were obtained between 0.234 -116.50 μg/mL and this plant inhibited HMG_CoA R and glucosidase enzymes more with IC 50 values of 0.234 and 116.50 μg/mL, respectively. Among the 11 secondary metabolites identified in T. hypochionaeus extract, chlorogenic acid 255.459 � 1.17 μg g À 1 ), benzoic acid (56.251 � 1.98 μg g À 1 ), and catechin (29.029 � 0.27 μg g À 1 ) were determined as the most abundant phenolic compounds. According to the results of the tested microorganisms, the plant extracts showed antimicrobial and antifungal properties in a dose-dependent manner. In molecular docking study, the interactions of active compounds extracted from Turanecio hypochionaeus plant and showing activity against diverse metabolic enzymes were examined. The most active compound 1, (chlorogenic acid) has À 12.80, À 12.80, À 12.60 and À 12.00 kcal/mol binding energy value against HMG_CoA R, and α-amylase, α-glucosidase, and lipase, respectively.

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“…The structures of ureases, the structure and number of subunits, molecular weights, and amino acid sequences are different according to the way they are obtained from various sources. The proteins of the fungal and plant urease subunits are homohexameric, while the two or three subunit complexes of bacterial ureases are multimeric 6) . Tyrosinase (EC 1.14.18.1) is also known as polyphenol oxidase, monophenol oxidase, phenolase, or catecholase.…”

mentioning

confidence: 99%

Anti-breast Adenocarcinoma and Anti-urease Anti-tyrosinase Properties of 5-Pentylresorcinol as Natural Compound with Molecular Docking Studies

Yang

Zhao

et al. 2022

J. Oleo Sci.

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IntroductionNatural compounds play a significant role in cancer treatment with substantial numbers of anticancer factors utilized in the clinic being either derived or natural from important products from various sources like animals, plants, and microorganisms 1) . 5-Pentylresorcinol (Fig. 1) compound is a naturally happening organic molecule. It is recorded in particular species of lichens that can be readily extracted, also, it is also a precursor in various syntheses of tetrahydrocannabinol. This compound was used as a template molecule in the synthesis of molecularly imprinted polymer. It was also used as an inhibitor of (S) -mephenytoin 4′ -hydroxylase activity of recombinant CYP2C19 2) . Additionally, it is also produced by several insects, either # means Xiaopeng Yang and Zhenyu Zhao have contributed equally to this work.

show abstract

Structure and urease inhibitory activity of copper(II) complex with (E)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylic acid

Cited by 9 publications

References 29 publications

Recent advances in design of new urease inhibitors: A review

Recent advances in design of new urease inhibitors: A review

Turanecio hypochionaeus: Determination of Its Polyphenol Contents, and Bioactivities Potential Assisted with in Silico Studies

Anti-breast Adenocarcinoma and Anti-urease Anti-tyrosinase Properties of 5-Pentylresorcinol as Natural Compound with Molecular Docking Studies

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