Structure, apatite inducing ability, and corrosion behavior of chitosan/halloysite nanotube coatings prepared by electrophoretic deposition on titanium substrate

Molaei, A.; Amadeh, A.; Yari, Mohammad; Afshar, M. Reza

doi:10.1016/j.msec.2015.10.073

Cited by 76 publications

(20 citation statements)

References 54 publications

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“…The analysis was conducted using deionized water as a dispersant at neutral pH. Ideal dispersion and charging of HNTs in a wide variety of pH are possible due to the inner and outer hydroxyl groups, which act as major reactive sites [ 37 ]. It is apparent from Figure 2 that the surface charge of HNTs reaches an average value of approximately −30 mV.…”

Section: Resultsmentioning

confidence: 99%

Chitosan-Coated Halloysite Nanotubes As Vehicle for Controlled Drug Delivery to MCF-7 Cancer Cells In Vitro

et al. 2021

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The aim of the work is to improve the release properties of curcumin onto human breast cancer cell lines using coated halloysite nanotubes (HNTs) with chitosan as a polycation. A loading efficiency of 70.2% (w/w) was attained for loading 4.9 mg of the drug into 0.204 g bed volume of HNTs using the vacuum suction method. Results acquired from Brunauer-Emmett-Teller (BET), Fourier-transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), scanning electron spectroscopy (SEM), zeta potential, and thermogravimetric analysis (TGA) indicated the presence of the drug and the biopolymer in and around the nanotubes. The release properties of drug-loaded HNTs (DLHNTs) and chitosan-coated drug-loaded HNTs (DLHNTs-CH) were evaluated. The release percentages of DLHNTs and DLHNTs-CH after 6 h were 50.7 and 37%, respectively. Based on the correlation coefficients obtained by fitting the release nature of curcumin from the two samples, the Korsmeyer-Peppas model was found to be the best-fitted model. In vitro cell viability studies were carried out on the human breast cancer cell line MCF-7, using the MTT and trypan blue exclusion assays. Prior to the Trypan blue assay, the IC50 of curcumin was determined to be ~30 µM. After 24 h of incubation, the recorded cell viability values were 94, 68, 57, and 51% for HNTs, DLHNTs-CH, DLHNTs, and curcumin, respectively. In comparison to the release studies, it could be deducted that sustained lethal doses of curcumin were released from the DLHNTs-CH within the same time. It is concluded from this work that the “burst release” of naked drugs could be slowly administered using chitosan-coated HNTs as potential drug carriers.

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Section: Resultsmentioning

confidence: 99%

Chitosan-Coated Halloysite Nanotubes As Vehicle for Controlled Drug Delivery to MCF-7 Cancer Cells In Vitro

et al. 2021

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“…These were relatively to somewhat strong as the HNC loadings increased in the CTH hydrogel composites. In the case of CTH0.5 to CTH4 samples, there was no peak relating to the CT at 2θ = 9.25° meaning that the CT was deposited in the amorphous form …”

Section: Resultsmentioning

confidence: 99%

Chitin‐halloysite nanoclay hydrogel composite adsorbent to aqueous heavy metal ions

Nguyen

Trang

Kobayashi

2018

J of Applied Polymer Sci

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Halloysite nanoclay (HNC) was mixed with Chitin hydrogel film by phase inversion in water vapor atmosphere at room temperature. In the preparation, Chitin was dissolved in N,N‐dimethyl acetamine/lithium chloride (DMAc/LiCl) and different amounts of HCN was dispersed well for the gelation process. The resultant Chitin‐Halloysite nanoclay (CTH) hydrogel films containing HCN at 0, 0.1, 0.5, 1, and 4 wt % were used for the adsorbents of heavy metal ions. As the results, the tensile strength of the hydrogel composite was enhanced from 0.34 to 0.71 N/mm2 while the elongation decreased from 66.43% to 49.93% with the increment of HNC concentration from 0 to 4 wt %. A reduction in the water content and the increment in the modulus confirmed the formation of highly dispersed nano‐composites with improved interfacial interactions between nano‐fillers and matrix. In the adsorption experiments of the ternary ion of Pb2+, Cu2+, and Cd2+, the removal capacity of Pb(II) was highly retained by the CTH hydrogel film relative to Cd(II) and Cu(II), shown Langmuir model with the maximum binding amount on the hydrogel composites were followed as order Pb (8.2 mg/g), Cu (4.2 mg/g), and Cd (2.1 mg/g). © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47207.

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“…Radiographs and lymphocyte transformation testing (LTT) confirmed the femoral loosening and nickel (Ni) sensitivity, respectively, which led to revisionary surgery using an Ni-free implant. The radiograph shown in Figure 9 Considering the painful fact that many individuals have to go through this around the globe, researchers are investigating how to enhance the corrosion resistance of metal implants [128][129][130]. Gebhardt et al [80] characterized the EPD of chitosan on 316L-SS substrate.…”

Section: Epd Of Chitosan-based Coatingsmentioning

confidence: 99%

A Brief Insight to the Electrophoretic Deposition of PEEK-, Chitosan-, Gelatin-, and Zein-Based Composite Coatings for Biomedical Applications: Recent Developments and Challenges

et al. 2021

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Electrophoretic deposition (EPD) is a powerful technique to assemble metals, polymer, ceramics, and composite materials into 2D, 3D, and intricately shaped implants. Polymers, proteins, and peptides can be deposited via EPD at room temperature without affecting their chemical structures. Furthermore, EPD is being used to deposit multifunctional coatings (i.e., bioactive, antibacterial, and biocompatible coatings). Recently, EPD was used to architect multi-structured coatings to improve mechanical and biological properties along with the controlled release of drugs/metallic ions. The key characteristics of EPD coatings in terms of inorganic bioactivity and their angiogenic potential coupled with antibacterial properties are the key elements enabling advanced applications of EPD in orthopedic applications. In the emerging field of EPD coatings for hard tissue and soft tissue engineering, an overview of such applications will be presented. The progress in the development of EPD-based polymeric or composite coatings, including their application in orthopedic and targeted drug delivery approaches, will be discussed, with a focus on the effect of different biologically active ions/drugs released from EPD deposits. The literature under discussion involves EPD coatings consisting of chitosan (Chi), zein, polyetheretherketone (PEEK), and their composites. Moreover, in vitro and in vivo investigations of EPD coatings will be discussed in relation to the current main challenge of orthopedic implants, namely that the biomaterial must provide good bone-binding ability and mechanical compatibility.

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Structure, apatite inducing ability, and corrosion behavior of chitosan/halloysite nanotube coatings prepared by electrophoretic deposition on titanium substrate

Cited by 76 publications

References 54 publications

Chitosan-Coated Halloysite Nanotubes As Vehicle for Controlled Drug Delivery to MCF-7 Cancer Cells In Vitro

Chitosan-Coated Halloysite Nanotubes As Vehicle for Controlled Drug Delivery to MCF-7 Cancer Cells In Vitro

Chitin‐halloysite nanoclay hydrogel composite adsorbent to aqueous heavy metal ions

A Brief Insight to the Electrophoretic Deposition of PEEK-, Chitosan-, Gelatin-, and Zein-Based Composite Coatings for Biomedical Applications: Recent Developments and Challenges

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