Structure elucidation of a flavonoid glycoside from the roots of Clerodendrum serratum (L.) Moon, Lamiaceae

Abstract

foi isolado pela primeira vez das raízes de Clerodendrum serratum (L.) Moon, Lamiaceae. A elucidação estrutural da susbtância foi feita através de estudos de 1 H NMR e FAB-MS. Unitermos:ABSTRACT: Apigenin-7-glucoside, C 21 H 20 O 10 (7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one), was first time isolated from the roots of Clerodendrum serratum (L.) Moon, Lamiaceae. Structure elucidation of the compound was carried out by 1 H NMR and FAB-MS studies.

Phytochemical profile, nutraceutical potential and functional properties of Cucumis melo L. seeds

“…Vanillic acid exhibits antibacterial property and hydroxybenzoic acid has antifungal and antimicrobial activities . Naringenin‐7‐O‐glycoside is also a flavonoid, which proves to have antioxidant and antitumor effects …”

“…41 Naringenin-7-O-glycoside is also a flavonoid, which proves to have antioxidant and antitumor effects. 42 To the best of our knowledge there are few scientific papers on the phenolic composition of Cucumis melo seeds. Naringenin-7-O-glycoside was the major compound in melon seeds (4.30 mg 100 g −1 ) whereas 3-hydrohybenzoic acid was an abundant compound in melon peels (33.45 mg 100 g −1 ).…”

Promising Natural Products in Crop Protection and Food Preservation: Basis, Advances, and Future Prospects

“…Phytochemicals such as alkaloids, coumarins, flavonoids, tannins, and terpenoids were identified in hydroalcoholic extracts of C. citratus leaves [178] and extracts from T. arjuna bark, fruits, stem, and leaves [233], while fifteen phenolic compounds including naringenin-7-Oglycoside, gallic acid, vanillic acid, and 4-hydroxybenzoic acid were identified in C. melo L. seeds [232]. ese extracts contribute to nutritional, organoleptic, anticancer, anti-inflammatory, antimutagenic, antimicrobial, and antioxidant properties of foods to which they are applied [234][235][236]. In a related development, Aloe vera gel was utilized as a fruit coating in the preservation of C. papaya, raspberry, and Manilkara zapota L. fruit.…”

Clerodendrum serratum extract attenuates production of inflammatory mediators in ovalbumin-induced asthma in rats

“…Among numerous drugs of natural origin, the genus Clerodendrum has been used ethnomedicinally for treatment of many diseases such as, asthma, rheumatism, leucoderma in many countries of Asian continent. The biological effects of various species of Clerodendrum including C. serratum has been related to numerous category of bioactive principles including, terpenoids (serratumin A, serratoside A and B, oleanolic acid (Figure 1), queretaroic acid; flavonoids and their glycosides (7, 40-trihydroxy-30-methoxyflavone, 6,7-trihydroxy-40methoxyflavone; 7-glucopyranoside, scutellarein, apigenin-7-O-glucuronide; steroids (aspinasterol, stigmasterol, campesterol, β-sitosterol) and others as cinnamic acid, iscosahydropicenic acid, ursolic acid, squalene, methyl palmitate, hexadecenoic acid (9,10,11,12,13,14,15,16). These phytocompounds have exhibited considerable pharmacological activities including antifertility, anticancer, antioxidant, hepatoprotective, immunomodulator, antiiflammatory, wound healing and spermicidal in preclinical studies [17,18,19,20,21,22,23,24]…”