Structure-function relationship in a series of glaucoma cases

Sánchez-Pulgarín, M.; Saenz-Frances, Federico; Martínez-de-la-Casa, J.M.; García‐Feijoó, Julián; Ferreras-Amez, A; Júlvez, Luis Pablo

doi:10.1016/j.jfo.2019.07.009

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…Structural and functional relationships reach their peak at the advanced stage of the disease [16]. At early and late stages of glaucoma, there may be contradictions between OCT and SAP [17][18][19][20].…”

Section: Glaucoma Optic Neuropathymentioning

confidence: 99%

Morphofunctional Changes of the Retina and Optic Nerve in Optical Neuropathy of Various Genesis: A Literature Review

Zhukova¹,

Юрьева²,

Samsonov³

2023

Optical Coherence Tomography - Developments and Innovations in Ophthalmology

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The retina is part of the central nervous system and has much in common with the brain’s physiological characteristics. Ophthalmological manifestations often precede the symptoms of central nervous system disorders and are used for their early diagnosis. Retinal imaging is simpler and more economical than the available central nervous system imaging methods. In this connection, the search for retinal biomarkers of neurodegenerative diseases is relevant. Optical coherence tomography is highly valuable both for routine clinical practice and for research purposes. Different patterns of structural changes of the optic nerve and retina in optical neuropathies of various genesis are due to differences in the pathogenesis of diseases (glaucoma optic neuropathy, non-arterial anterior ischemic optic neuropathy, optic neuritis associated with multiple sclerosis, and compression optic neuropathy). The identified biomarkers can be used for screening patients in primary healthcare institutions to provide a preliminary diagnosis of patients at risk.

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Section: Glaucoma Optic Neuropathymentioning

confidence: 99%

Morphofunctional Changes of the Retina and Optic Nerve in Optical Neuropathy of Various Genesis: A Literature Review

Zhukova¹,

Юрьева²,

Samsonov³

2023

Optical Coherence Tomography - Developments and Innovations in Ophthalmology

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“…It is well known that, in different stages of POAG, the nature and location of the VF damage vary, and the trends in the pRNFLT change with varying degrees of VF defects [ 17 ]. Thus, the range of disease severity influences the inferred structure–function relationship [ 1 , 18 ]. When using this cluster method to combine regional structure and function measurements for clinical decision-making and further research, whether the results from the overall POAG population could be applied to patients belonging to a certain stage, this needs further research.…”

Section: Introductionmentioning

confidence: 99%

Structure-Function Relationship between Cluster Mean Defect and Sector Peripapillary Retinal Nerve Fiber Layer Thickness in Primary Open Angle Glaucoma

Han

Yang

Wang

et al. 2022

Journal of Ophthalmology

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Purpose. To determine the structure–function relationship between cluster mean defect (MD) offered by standard automated perimetry and corresponding sector peripapillary retinal nerve fiber layer thickness (pRNFLT) measured with optical coherence tomography (OCT) in primary open angle glaucoma (POAG). Method. 39 healthy eyes (control group), 43 early POAG eyes (global MD ≤ 6 dB, early group), 30 moderate POAG eyes (global MD between 6 and 12 dB, moderate group), and 53 advanced POAG eyes (global MD > 12 dB, advanced group) underwent visual field (VF) examination with Octopus perimeter (dynamic strategy/G2 pattern) and peripapillary retinal nerve fiber layer thickness measurements with RTVue-100 FD-OCT. Spearman analysis was used to investigate the correlation between cluster MDs provided by Octopus perimeter and corresponding sector pRNFLT for the total sample and each subgroup, respectively. Then, linear (y = a+ bx) and curvilinear (quadratic, y = a+bx + cx2) regression analyses were employed to investigate the model for the cluster MD-sector pRNFLT pair with significant correlation. The strength of the relationship was characterized with correlation coefficient (ρ) and coefficient of determination (R2). For the cluster–sector pair that could be fitted by both models, Wilcoxon signed rank test of absolute residuals was used to compare the goodness of fit. Results. Correlation between cluster MDs and corresponding sector pRNFLT was significant for all clusters in the total sample (ρ values: −0.572 to 0.832, P < 0.001 ) and in the POAG group (ρ values: −0.551 to −0.777, P < 0.001 ). The highest ρ values were found for cluster-sector pair 9 and pair 3, respectively. The curvilinear (quadratic) model provided better fit for all 10 cluster-sector pairs in the total sample (R2 values: 0.431–0.687, P < 0.001 ) and in the POAG group (R2 values: 0.364–0.594, P < 0.01 ). The highest R2 values were found also for cluster–sector pair 9 and pair 3, respectively. In the control group, no significant correlation was found for any cluster–sector pair ( P > 0.01 ). In the early group, correlation was significant for cluster–sector pairs 3, 8, and 9 (ρ values: −0.449, −0.627, and −0.815, resp., P < 0.01 ). In the moderate group, correlation was significant for pairs 2, 3, 8, and 9 (ρ values: −0.703, −0.556, −0.680, and −0.637, resp., P < 0.01 ). In the advanced group, correlation was significant ( P < 0.01 ) for all 10 pairs (ρ values: −0.395 to −0.699, P < 0.001 ) except for pairs 2, 3, and 8, and the highest ρ value was found for pair 1. For all cluster–sector pairs with significant correlation in the early, moderate, and advanced groups, only linear model could be fitted ( P < 0.01 ), except for pair 9 in the early group and pair 5 in the advanced group. Conclusions. Cluster MD of the Octopus visual field showed significant moderate-to-strong negative correlation and curvilinear (quadratic) relationship with the corresponding sector pRNFLT for POAG. This type of regional structure–function relationship varied according to the severity of POAG, and at each stage, the significantly correlated cluster–sector pairs mainly showed linear relationship. The results could provide guidance for better utilization of this regional structure–function method in the management of different stages of POAG.

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Офтальмологічна Характеристиката Прогноз Стадій Первинної Відкритокутової Глаукоми

Maidenko¹

2022

AOU

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Актуальність. Існуюче лікування неспроможне відновити глаукоматозне пошкодження ока, однак оптимізація діагностики може запобігти прогресуванню глаукоми та сліпоті. Мета: вивчити офтальмологічні показники при первинній відкритокутовій глаукомі (ПВКГ) різних стадій та оцінити можливість їх прогнозу. Матеріали та методи. Обстежені 92 пацієнти (179 очей) віком від 34 до 91 року (69,5 ± 0,7 року), серед яких жінок було 53 %, чоловіків — 47 %. До контрольної групи увійшло 45 очей без патології. Усім пацієнтам проводили офтальмоскопію, візометрію, периметрію, пневмотонометрію та оптичну когерентну томографію (ОКТ) з визначенням товщини шарів нервових волокон сітківки (RNFL, мкм), комплексу гангліозних клітин макули (GCC, мкм), локального (FLV, %) і загального (GLV, %) потоншення комплексу гангліозних клітин сітківки. Статистичну обробку проводили у програмі EZR v. 1.54 (Австрія) та з використанням модуля лінійних та нелінійних моделей (GLZ) Statistica 10 (StatSoft, Inc., США). Результати. Встановлена пряма лінійна залежність віку та стадії ПВКГ (R2adjusted = 0,70). Гострота зору зменшувалася за стадіями ПВКГ (p < 0,001), тоді як значення середнього та стандартного відхилень при периметричному обстеженні (MD та PSD) наростали (p < 0,001). Товщина RNFL суттєво зменшувалася з мінімальними значеннями при III і IV стадіях (p < 0,001), тоді як FLV і GLV наростали на очах з II і, більшою мірою, III та IV стадіями ПВКГ (p < 0,001). Аналіз стану парних очей показав, що переважна більшість пар (88,4 %) мала однакові стадії ПВКГ або незначну різницю (не більше ніж на 1 стадію). Розроблена модель ймовірності стадії ПВКГ, яка включила MD, RNFL, GCC, FLV і GLV та має точність прогнозу 80,1 % (95% ВІ 73,8–85,7 %). Висновки. Отримані результати дозволили розробити лінійну регресійну модель стадій ПВКГ на підставі комплексної оцінки MD, RNFL та інших показників ОКТ, що може бути клінічно значущим методом діагностики.

show abstract

Structure-function relationship in a series of glaucoma cases

Cited by 5 publications

References 15 publications

Morphofunctional Changes of the Retina and Optic Nerve in Optical Neuropathy of Various Genesis: A Literature Review

Morphofunctional Changes of the Retina and Optic Nerve in Optical Neuropathy of Various Genesis: A Literature Review

Structure-Function Relationship between Cluster Mean Defect and Sector Peripapillary Retinal Nerve Fiber Layer Thickness in Primary Open Angle Glaucoma

Офтальмологічна Характеристиката Прогноз Стадій Первинної Відкритокутової Глаукоми

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