Structure of 7-chloro-5-(2-fluorophenyl)-1,3,4,5-tetrahydro-1,4-dimethyl-2H-1,4-benzodiazepin-2-one monohydrate

Chananont, P.; Hamor, T. A.; Martín, Ignació

doi:10.1107/s0567740880006954

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1982

1994

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Cited by 7 publications

(2 citation statements)

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“…0108-2701/87/112195-04501.50 Hamor & Martin, 1983;Butcher & Hamor, 1985) but only one of them has shown a solvate molecule (Chananont, Hamor & Martin, 1980). In our study on the polymorphism of lorazepam we have recrystallized the molecule from five solvents (Rambaud, Maury, Pauvert, Delarbre & Lasserre, 1987) and have found five different solvates.…”

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confidence: 99%

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Structures of lorazepam isopropyl alcohol solvate (I) and isoamyl alcohol solvate (II)

Rambaud¹,

Delarbre²,

Pauvert³

et al. 1987

Acta Crystallogr C

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confidence: 99%

“…They found a formulation in which one ethanol molecule is present for two lorazepam molecules. Several structural studies of benzodiazepines have been published since then (Gilli, Bertolasi, Sacerdoti & Borea, 1977, 1978aChananont, Hamor & Martin, 1980, 1981Butcher, * Lorazepam: 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-l,4-benzodiazepin-2-one.…”

mentioning

confidence: 99%

Structures of lorazepam isopropyl alcohol solvate (I) and isoamyl alcohol solvate (II)

Rambaud¹,

Delarbre²,

Pauvert³

et al. 1987

Acta Crystallogr C

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NMR of some benzodiazepine drugs: Structure elucidation with lanthanide‐induced shifts of N‐1 substituted benzodiazepinones

1983

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Two 1,4-benzodiazepinones of psychopharmacological interest, pinazepam (2) andprazepam (3),were studiedin solution by OC and 'H NMR. 'H variable-temperature experiments showed that the seven-membered ring exists in a simple pseudo-boat form at room temperature, but the energy barrier is higher in 3 (AG405sC = 82.8 kJ mol-') than in diazepam (1). Moreover, upon addition of LSR, the boat conformation is retained in the lanthanide ion-substrate complex, as with 1 in the solid state. Using a concentrationdependent shift technique and a computer-assisted LIS method, the conformations of the N-branched side-chain were investigated. Two preferred orientations were found for the propargyl group of 2, while three unequally populated conformations of the cyclopropyl moiety of 3 are distributed preferentially in the s t e r i d y unhindered space around the complex.

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Synthesis and structure of 1,4-diacetyl-1,2,5-thiadiazolo-[4,3-e]-1,2,3,4-tetrahydro-5H-1,4-diazepin-5-one

Simonov¹,

Dvorkin²,

Иванов³

et al. 1994

J Struct Chem

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Structure of 7-chloro-5-(2-fluorophenyl)-1,3,4,5-tetrahydro-1,4-dimethyl-2H-1,4-benzodiazepin-2-one monohydrate

Cited by 7 publications

References 1 publication

Structures of lorazepam isopropyl alcohol solvate (I) and isoamyl alcohol solvate (II)

Structures of lorazepam isopropyl alcohol solvate (I) and isoamyl alcohol solvate (II)

NMR of some benzodiazepine drugs: Structure elucidation with lanthanide‐induced shifts of N‐1 substituted benzodiazepinones

Synthesis and structure of 1,4-diacetyl-1,2,5-thiadiazolo-[4,3-e]-1,2,3,4-tetrahydro-5H-1,4-diazepin-5-one

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