Structure of C60 fullerene in water: spectroscopic data

Scharff, P.; Risch, K.; Carta‐Abelmann, L.; Dmytruk, I. M.; Bilyi, M. M.; Golub, O.A.; Khavryuchenko, A.V.; Buzaneva, E. V.; Аксенов, В. Л.; Авдеев, М. В.; Prylutskyy, Yu. І.; Durov, S. S.

doi:10.1016/j.carbon.2003.12.053

Cited by 147 publications

(166 citation statements)

References 6 publications

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“…The results (not shown) agree with literature data well, indicating that C 60 fullerene aqueous solution was formed (see Ref. 18 and references therein).…”

Section: A Preparation Of Pristine C 60 Fullerene Aqueous Solutionsupporting

confidence: 89%

“…The pristine C 60 fullerene aqueous colloid solutions (C 60 FAS) used in the experiments were prepared as follows: 18,19 a saturated solution of C 60 fullerene (99.5% purity) in toluene was mixed with the same amount of distilled water and the resulted two-phase system was subjected to the ultrasonic treatment until a completion of the toluene evaporation. Afterwards, the yellow-colored water phase was filtered for removing the un-dissolved C 60 fullerenes.…”

Section: A Preparation Of Pristine C 60 Fullerene Aqueous Solutionmentioning

confidence: 99%

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Evidence of entropically driven C60 fullerene aggregation in aqueous solution

Voronin

Buchelnikov

Kostjukov

et al. 2014

The Journal of Chemical Physics

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“…The results (not shown) agree with literature data well, indicating that C 60 fullerene aqueous solution was formed (see Ref. 18 and references therein).…”

Section: A Preparation Of Pristine C 60 Fullerene Aqueous Solutionsupporting

confidence: 89%

Section: A Preparation Of Pristine C 60 Fullerene Aqueous Solutionmentioning

confidence: 99%

Evidence of entropically driven C60 fullerene aggregation in aqueous solution

Voronin

Buchelnikov

Kostjukov

et al. 2014

The Journal of Chemical Physics

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“…The AFM picture (Fig. 1) clearly demonstrates the presence of single C6fl molecules in water, as well as their clusters with a typical 2-100-nm range of diameters, which is in agreement with theoretical calculations (Bulavin et al 2000;Prylutskyy et al 1999Prylutskyy et al , 2001), a small-angle neutron (Scharff et al 2004) and dynamic light scattering ) data.…”

Section: Compoundssupporting

confidence: 87%

“…C6fl fullerene: The pristine C6fl fullerene aqueous colloidal solution (C6flFAS) used for the experiments was prepared as follows (Prylutska et al 2007b;Scharff et al 2004): a saturated solution of C6fl fullerene (purity 99.5 %) in tolu ene was mixed with the same amount of distilled water, and the resulting two-phase system was ultra-sonicated until the toluene had completely evaporated. Following this, the yellow-colored water phase was filtered to remove undis solved C6fl fullerene.…”

Section: Compoundsmentioning

confidence: 99%

Interceptor effect of C60 fullerene on the in vitro action of aromatic drug molecules

et al. 2014

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C60 fullerenes are spherical molecules com posed purely of carbon atoms. They inspire a particularly strong scientific interest because of their specific physico chemical properties and potential medical and nanotech nological applications. In this work we are focusing on studying the influence of the pristine C60 fullerene on bio logical activity of some aromatic drug molecules in human buccal epithelial cells. Assessment of the heterochromatin structure in the cell nucleus as well as the barrier function of the cell membrane was performed. The methods of cell microelectrophoresis and atomic force microscopy were also applied. A concentration-dependent restoration of the functional activity of the cellular nucleus after exposure to DNA-binding drugs (doxorubicin, proflavine and ethidium bromide) has been observed in human buccal epithelial cells upon addition of C60 fullerene at a concentration of -1СГ5 M. The results were shown to follow the framework of interceptor/protector action theory, assuming that noncovalent complexation between C60 fullerene and the drugs (i.e., hetero-association) is the major process responsible for the observed biological effects. An independent con firmation of this hypothesis was obtained via investigation of the cellular response of buccal epithelium to the coad ministration of the aromatic drugs and caffeine, and it is based on the well-established role of hetero-association in drug-caffeine systems. The results indicate that C60 fuller ene may reverse the effects caused by the aromatic drugs, thereby pointing out the potential possibility of the use of aromatic drugs in combination with C60 fullerene for regu lation of their medico-biological action.

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“…Fullerene C 60 is insoluble in water, but creates stable aggregates with nanoscale dimensions, nC 60 (25-500 nm) [24][25][26][27]. Aggregates remain in suspension for a long time [28] and their reactivity differs from separate C 60 molecules.…”

Section: Introductionmentioning

confidence: 99%

Rapid insight into C60 influence on biological functions of proteins

et al. 2017

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Experimental methods of investigations of nanoparticle (NP)-protein interactions are limited, because they require a high amount of samples and the NPs tend to interfere with spectral results. Therefore, molecular modeling is a commonly accepted tool in such kind of investigations. Examining the molecule toxicity on the molecular level, we usually want to know, mainly, the location of the ligand on the protein surface and what is an influence of such a contact on the biological functions of the protein. In the presented work, we demonstrate that multiple-docking of the ligand from a random start and with large grid volume, to let the ligand search the whole protein surface, allows to find the best binding sites and gives reliable results considering ligand-protein interactions. In the present work, we have constructed six models of bronchoalveolar lavage fluids proteins: α1-antitripsin, albumin, ceruloplasmin, lactoferrin, lysozyme, and transferrin with fullerene, C 60 utilizing molecular docking methods. The most probable results were examined with steered molecular dynamics (SMD) to see, if the simple docking method is able to predict the fullerene binding affinity. Albumin and lysozyme were already widely investigated and literature data is available for their complexes with fullerene C 60 and/or its derivatives. Thus, we used these two models as a reference set to validate the used molecular modeling methods. With our best knowledge, interactions of the remaining four proteins with NPs have never been investigated in detail before. Our results indicate that fullerene C 60 readily interacts with all studied proteins and may have a large impact on their biological functions.

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Structure of C60 fullerene in water: spectroscopic data

Cited by 147 publications

References 6 publications

Evidence of entropically driven C60 fullerene aggregation in aqueous solution

Evidence of entropically driven C60 fullerene aggregation in aqueous solution

Interceptor effect of C60 fullerene on the in vitro action of aromatic drug molecules

Rapid insight into C60 influence on biological functions of proteins

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