Background: Numerous restorations have been used in dentistry to substitute the lost natural tooth structure. In attempts to improve the mechanical properties of glass ionomer, a nano-zirconia reinforced glass ionomer was introduced. The aim of the study was to compare the impact of cyclic stresses on flexural strength of two aesthetics restorative materials. Materials and methods: A nano-hybrid composite resin and a nano-zirconia reinforced glass ionomer were used in this study. A total of 80 specimens, 40 for each restorative were fabricated. In each group, 10 specimens were assigned for each aging condition as following; control, thermo-cyclic stresses, mechanical-cyclic stresses and combined thermomechanical cyclic stresses. Then the specimens were submitted to 3-point loading test using the Universal Testing Machine. Results: In all test conditions, nano-hybrid composite resin showed statistically significant higher mean flexural strength than nano-zirconia reinforced glass ionomer (61.1MPa SD ±17.3, 24.2 MPa SD ± 9.9 P-value <0.001). The control condition showed the highest statistically significant mean flexural strength (59.4 MPa SD± 26.8, P-value<0.001), while the combined condition showed the lowest statistically significant mean of flexural strength (29.7 MPa, SD±15.9, P-value <0.001). Conclusions: Nano-hybrid composite showed superior performance than zirconia reinforced glass ionomer when subjected to cyclic stresses; either thermal, mechanical or combined.