Structure of lansiosides: biologically active new triterpene glycosides from Lansium domesticum

Nishizawa, Masatoyo; Nishide, Hisaya; Kosela, Soleh; Hayashi, Yûji

doi:10.1021/jo00172a004

Cited by 45 publications

(41 citation statements)

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“…Several onoceranoid-type triterpenoids have been isolated from L. domesticum peels [38,39]. Previous reports have described the bioactivities of these onoceranoid-type triterpenoids, such as toxicity against brine shrimp [37], inhibition of leukotriene D4-induced contraction of the guinea pig ileum [40], cytotoxic activity [41], and antibacterial activity against Gram-positive bacteria [42]. However, the bioactivities of these onoceranoid-type triterpenoids have not been investigated thoroughly.…”

Section: Compounds Obtained From the Leaves Of L Domesticummentioning

confidence: 99%

“…Therefore, we attempted to isolate this class of triterpenoids for investigating their biological effects. 45, and XII (46) together with nine known compounds, lansiolic acid (47) [40], methyl lansiolate (48) [40], ethyl lansiolate (49) [42], lansioside C (50) [40], lansioside B (51) [40], 8,14-seco-gammacera-7,14-diene-3, 21-dione (52) [43], lansionic acid (53) [37], lansic acid (54) [37], and lamesticumin A (55) [42] were isolated (Fig. 3).…”

Section: Compounds Obtained From the Leaves Of L Domesticummentioning

confidence: 99%

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Isolation and structure elucidation of constituents of Citrus limon, Isodon japonicus, and Lansium domesticum as the cancer prevention agents

Μatsumoto

Watanabe

2020

Genes and Environ

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In the course of our research to investigate the cancer prevention potency of natural products derived from plant materials, we isolated fifty-five compounds, including twenty-one new compounds from the peels of Citrus limon, aerial parts of Isodon japonicus, and leaves of Lansium domesticum. The chemical structures of the isolated compounds were elucidated by chemical/physicochemical evidence, and nuclear magnetic resonance spectroscopy and mass spectrometry results. Moreover, the absolute stereochemistry of the new compounds were elucidated by various techniques such as chemical synthesis, modified Mosher's method, Cu-Kα X-ray crystallographic analysis, and comparison of experimental and predicted electronic circular dichroism data. The antimutagenic effects of the isolated and structure-elucidated compounds against heterocyclic amines, 3-amino-1,4-dimethyl-5H-pyrido [4,3b]indole (Trp-P-1) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), were evaluated by the Ames test and in vivo micronucleus test. In this review, we present the comprehensive results of the antimutagenic effects of the isolated natural products.

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Section: Compounds Obtained From the Leaves Of L Domesticummentioning

confidence: 99%

Section: Compounds Obtained From the Leaves Of L Domesticummentioning

confidence: 99%

Isolation and structure elucidation of constituents of Citrus limon, Isodon japonicus, and Lansium domesticum as the cancer prevention agents

Μatsumoto

Watanabe

2020

Genes and Environ

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“…al., 2011). smoke from buwan(Lansiumdomesticum ) fruit peelings Indicated the presence of triterpene glycosides and seco-onoceranoids such as lansic acid which can be attributed to its toxicity (Nishizawa, et. al., 1983).…”

Section: Substitutesmentioning

confidence: 99%

Ethnochemistry of Maguindanaons' on the Usage of Household Chemicals: Implications to Chemistry Education

Ador

2017

COES&RJ-JSS

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Integrating ethnochemistry into the curriculum may provide students meaningful learning in addition to preservation and appreciation towards the quality of their cultural heritage. Hence, the study aimed to document the indigenous usage of household chemicals of Maguindanaons through ethnography research using purposive and snowball sampling in the selected municipalities of Maguindanao Province. Interview, Focus Group Discussion (FGD) and observation were employed for data collection in the five (5)-month community immersion. The data were then thematically analysed. As revealed, they had utilized substitutes for paint, floor polishers, mosquito repellents, bath and laundry soaps, toothpastes, perfumes, shampoo and other cosmetics. Furthermore, the study found out that their indigenous usage of household chemicals conforms to standard chemical bases. Accordingly, the output of the study may serve as groundwork to develop culture-based lessons in high school Chemistry in the said locale.

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“…For compounds from this plant species, see: Habaguchi et al (1968); Kiang et al (1967); Nishizawa et al (1982Nishizawa et al ( , 1983Nishizawa et al ( , 1984Nishizawa et al ( , 1985Nishizawa et al ( , 1988; Saewan et al (2006).…”

Section: Related Literaturementioning

confidence: 99%

Kokosanolide from the seed ofLansium domesticumCorr.

et al. 2009

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Structure of lansiosides: biologically active new triterpene glycosides from Lansium domesticum

Cited by 45 publications

References 0 publications

Isolation and structure elucidation of constituents of Citrus limon, Isodon japonicus, and Lansium domesticum as the cancer prevention agents

Isolation and structure elucidation of constituents of Citrus limon, Isodon japonicus, and Lansium domesticum as the cancer prevention agents

Ethnochemistry of Maguindanaons' on the Usage of Household Chemicals: Implications to Chemistry Education

Kokosanolide from the seed ofLansium domesticumCorr.

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