Structure of large arteries: Orientation of elastin in rabbit aortic internal elastic lamina and in the elastic lamellae of aortic media

Contribution of elastin and collagen to the inflation response of the pig thoracic aorta: Assessing elastin's role in mechanical homeostasis

“…Collagen recruitment approached systolic in the proximal aorta but sub-diastolic in the distal. circumferential (Gundiah et al, 2006;Farand et al, 2007;Timmins et al, 2010) the interlamellar elastic fibers are nonorthogonal (Davis, 1993;O'Connell et al, 2008). If non-orthogonal fibers do contribute, the absence of observed torsion indicates they are axially symmetric.…”

Predisease biological markers: early diagnosis and prevention of arterial hypertension

“…The endothelial surface and intima of large vessels, with their macromolecular constituents-proteoglycans and fibronectin, respectively-are capable of triggering an increase in circulating blood cells and/or stimulating the adjacent matrix of the intima, including elastic fibers sensitive to changes in parallel flow [9][10][11][12]. In addition to the response of the aortic intima to increased pulse pressure, 2 other important structures are affected, namely, the vascular smooth muscle cell (VSMC) subpopulations (longitudinal and circular) and the interstitial matrix, which contains collagen, elastic material, and proteoglycans.…”

In Vivo Assessment of Aortic Aneurysm Wall Integrity Using Elastin-Specific Molecular Magnetic Resonance Imaging

“…Elastin, as the most abundant protein in the tunica media, provides the tensile strength of the arterial wall, enabling it to sustain mechanical stress resulting from high intravascular pressure and arterial pulsation. 9 The progressive breakdown of structural proteins, in particular, medial elastin, is responsible for the inability of the aortic wall to withstand the high intraluminal hemodynamic forces.10 Besides elastin, different forms of collagen play an important role in maintaining aortic Background-The incidence of abdominal aortic aneurysms (AAAs) has increased during the last decades. However, there is still controversy about the management of medium-sized AAAs.…”

“…Elastin, as the most abundant protein in the tunica media, provides the tensile strength of the arterial wall, enabling it to sustain mechanical stress resulting from high intravascular pressure and arterial pulsation. 9 The progressive breakdown of structural proteins, in particular, medial elastin, is responsible for the inability of the aortic wall to withstand the high intraluminal hemodynamic forces.…”