Structure of Pachygonine, A New Quaternary Alkaloid From Pachygone ovata

Anti-inflammatory and antinociceptive effect of Pachygone ovata leaves

“…The nociceptive effect of P. ovata also has been justified in the formalin induced pain model. The mechanism of antiinflammatory and antinociceptive activities from P. ovata may be explained by the presence of alkaloids such as coclaurine, reticuline, norjuzophine, trilobine (Dasgupta et al 1979;Bhat et al 1980) and different components of the plant acting simultaneously and amplifying the individual effect in a complimentary manner. In our study the alkaloid fraction alone was not as significant in terms of anti-inflammatory as compared with the methanol extract; this could be due to the complex mixture of phytochemicals from the plant acting through a combination of additive and/or synergic interactions also indicating that the pharmacological effect of P. ovata is dependent on other phytochemicals apart from the alkaloids alone in it.…”

“…has been an unexplored and trivialized plant from the Menispermaceae family despite containing a number of interesting alkaloids such as coclaurine, reticuline, trilobine, pachyovatamine (benzylisoquinoline alkaloids) magnoflurine (aporphine alkaloid), norjuziphine (benzyltetrahyroisoquinoline alkaloid), liriodenine, pachygonine (erythrina alkaloid), etc. (Dasgupta et al 1979;Bhat et al 1980;El-Kawi et al 1984;Uvais et al 1985). Traditionally only its use as a fish poison and vermicide has been highlighted (Hooker 1961;Kirtikar & Basu 1975).…”

Erythrina Alkaloids

“…The aqueous layer from this extraction was then acidified with hydrochloric acid and heated (60-70°) to hydrolyse the combined alkaloids; basifying and extraction with chloroform yielded the corresponding liberated' alkaloids. New quaternary alkaloids (N-methylated) have been isolated from the pod walls of E. arborescens [70][71][72] and from the roots of Pachygone ovata (Menispermaceae) [73]; the latter is the first report of occurrence of an Erythnna alkaloid outside the Erythrina and Cocculus genera. During the last twenty years or so, several groups have carried out major investigations of the alkaloid content of a variety of Erythnna species, notably those of Barton (in England) [28][29][30][31], Ito (in Japan) [32][33][34][35][36][37][38][39][40][41][42][43] and of Singh and Chawla [44][45][46][47][48][49][50] and Ghosal (in India) [51][52][53][54][55].…”

“…The evidence for the position of the aliphatic methoxyl group at C-3 was provided only by 73 115 in which aromatization of ring A has taken place without the loss of the methoxyl group. Oxidation of 115 with potassium permanganate gave 3-methoxyphthalic anhydride (116).…”

“…Erythroidines (71,73) were isolated from E.americana and characterised from their spectral properties, formation of quaternary ammonium salts and conversion of 71 to 73 by treatment with base [97]. From E.berteroana Chawla et α/.…”