1984
DOI: 10.1021/ja00329a043
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Structure of the major glycopeptide of the teicoplanin complex

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Cited by 75 publications
(26 citation statements)
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“…A possible explanation for the apparent increase in the terminal t112 after multiple-dose administration could be the in vivo presence of microbiologically active HP of teicoplanin. Loss of the N-acetylglucosamine and mannose side chains of teicoplanin results in more lipophilic aglycone moieties that retain some in vitro activity (1,2,6,8). In the aridicins, a novel series of glycopeptide antibiotics chemically related to teicoplanin, aglycone hydrolysis products exhibit more potent antistaphylococcal activity and prolonged serum tl/2s relative to the parent drug (10).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…A possible explanation for the apparent increase in the terminal t112 after multiple-dose administration could be the in vivo presence of microbiologically active HP of teicoplanin. Loss of the N-acetylglucosamine and mannose side chains of teicoplanin results in more lipophilic aglycone moieties that retain some in vitro activity (1,2,6,8). In the aridicins, a novel series of glycopeptide antibiotics chemically related to teicoplanin, aglycone hydrolysis products exhibit more potent antistaphylococcal activity and prolonged serum tl/2s relative to the parent drug (10).…”
Section: Discussionmentioning
confidence: 99%
“…Blood samples (7 ml) were obtained from a contralateral forearm vein before administration and at 5 (end of infusion), 10, 15, 30, and 45 minand 1, 2,3,4,6,9,12,24,36, and 48 h after dosing and then at 24-h intervals for a total of 25 days. Blood samples were allowed to clot at room temperature and centrifuged for 10 to 12 min, and the serum was immediately decanted and frozen at -80°C until analysis.…”
mentioning
confidence: 99%
“…The interpretations of all the signals were done by using 1H-'H two-dimensional correlations through three bonds by COSY phase-sensitive with doublequantum-filter (COSYPHDQ) experiments and through three and four bonds by COSY with relayed coherence transfer (COSYRCT) experiments. From the results of these experiments and by comparison with data on teicoplanin in the literature (1,10,11), it was found that both metabolites have the same structure as that shared by the five components of the teicoplanin complex, which differ only in the acyl chain. 2.02 1.43 1.14-1.26 1.44 Similarly, for the two metabolites, the high field part of 1H NMR spectrum unequivocally defines the acyl moiety.…”
Section: Methodsmentioning
confidence: 72%
“…The structures of its main components, A2-1, A2-2, A2-3, A2-4, and A2-5, and of the pseudoaglycones, A3-1 and A3-2, have recently been elucidated (2,3,6). Several minor constituents, designated A2-la, A2-lb, A2-1c, A2-ld, A2-le, A2-3a, and A2-5a, were also detectable by use …”
mentioning
confidence: 99%