Structure–Property Relationships of Trimetazidine Derivatives and Model Compounds as Potential Antioxidants

Ancerewicz, Jacek; Migliavacca, Eugenia; Carrupt, Pierre‐Alain; Testa, Bernard; Brée, F.; Zini, Roland; Tillement, Jean‐Paul; Labidalle, Serge; Guyot, D.; Chauvet-Monges, A. M.; Crevat, A.; Ridant, Alain Le

doi:10.1016/s0891-5849(98)00072-0

Cited by 169 publications

(86 citation statements)

References 41 publications

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“…DPPH is sensitive to some Lewis bases and solvent types as well as oxygen (Ancerewicz et al 1998). DPPH can only be soluble in organic solvent and the interference of absorbance from the sample compounds could be a problem for the quantitative analysis (Arnao 2000).…”

Section: Dpph Assaymentioning

confidence: 99%

Genesis and development of DPPH method of antioxidant assay

2011

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α, α-diphenyl-β-picrylhydrazyl (DPPH) free radical scavenging method offers the first approach for evaluating the antioxidant potential of a compound, an extract or other biological sources. This is the simplest method, wherein the prospective compound or extract is mixed with DPPH solution and absorbance is recorded after a defined period. However, with the advancement and sophistication in instrumental techniques, the method has undergone various modifications to suit the requirements, even though the basic approach remains same in all of them. This article presents a critical review on various developments to the DPPH method.

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Section: Dpph Assaymentioning

confidence: 99%

Genesis and development of DPPH method of antioxidant assay

2011

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“…The DPPH radical absorbs at 517 nm, but upon reduction by an antioxidant or a radical species its absorption decreases. When a hydrogen atom or electron was transferred to the odd electron in DPPH·, the absorbance at 517 nm decreased proportionally to the increases of non-radical forms of DPPH [38]. Briefly, 0.1 mM solution of DPPH· was prepared in ethanol and 0.5 mL of this solution was added to 1.5 mL of silymarin solution in ethanol at different concentrations (10-30 mg/mL).…”

Section: Dpphz Free Radical Scavenging Activitymentioning

confidence: 99%

In vitroantioxidant activity of silymarin

Köksal

Gülçın

Beyza

et al. 2009

Journal of Enzyme Inhibition and Medicinal Chemistry

203

100

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Silymarin, a known standardized extract obtained from seeds of Silybum marianum is widely used in treatment of several diseases of varying origin. In the present paper, we clarified the antioxidant activity of silymarin by employing various in vitro antioxidant assay such as 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH·) scavenging, 2,2 0 -azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging activity, total antioxidant activity determination by ferric thiocyanate, total reducing ability determination by Fe 3þ 2 Fe 2þ transformation method and Cuprac assay, superoxide anion radical scavenging by riboflavin/methionine/illuminate system, hydrogen peroxide scavenging and ferrous ions (Fe 2þ ) chelating activities. Silymarin inhibited 82.7% lipid peroxidation of linoleic acid emulsion at 30 mg/mL concentration; butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), a-tocopherol and trolox indicated inhibition of 83.3, 82.1, 68.1 and 81.3% on peroxidation of linoleic acid emulsion at the same concentration, respectively. In addition, silymarin had an effective DPPH· scavenging, ABTS zþ scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, ferric ions (Fe 3þ ) reducing power by Fe 3þ 2 Fe 2þ transformation, cupric ions (Cu 2þ ) reducing ability by Cuprac method, and ferrous ions (Fe 2þ ) chelating activities. Also, BHA, BHT, a-tocopherol and trolox, were used as the reference antioxidant and radical scavenger compounds. Moreover, this study, which clarifies antioxidant mechanism of silymarin, brings new information on the antioxidant properties of silymarin. According to the present study, silymarin had effective in vitro antioxidant and radical scavenging activity. It could be used in the pharmacological and food industry because of its antioxidant properties.

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“…It is commonly accepted that the first reaction step between an antioxidant and DPPH is the abstraction of a hydrogen atom from the antioxidant to give diphenylpicrylhydrazine (DPPH-H) and a phenoxyl radical [29] which will undergo further reactions such as dimerization, complexation and donation of a second hydrogen atom [30].…”

Section: Radical Scavenging Capacity Toward Dpphmentioning

confidence: 99%

Antioxidant properties of resveratrol and piceid on lipid peroxidation in micelles and monolamellar liposomes

Fabris

Momo

Ravagnan

et al. 2008

Biophysical Chemistry

159

102

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The antioxidant activities of trans-resveratrol (trans-3,5,4′-trihydroxystilbene) and trans-piceid (trans-5,4′-dihydroxystilbene-3-O-β-D-glucopyranoside), its more widespread glycosilate derivative, have been compared measuring their inhibitory action on peroxidation of linoleic acid (LA) and the radical scavenging ability towards different free radicals (such as DPPH) and radical initiators. It has been found that the two stilbenes have similar antioxidant capacity, while the comparison with BHT (2,6-di-tert-butyl-4-methylphenol) and α-tocopherol (vitamin E, vit. E), taken as reference, points out a slower but prolonged protective action against lipid peroxidation. Furthermore, piceid appears more efficacious than resveratrol as a consequence of the reaction of the latter with its radical form. The DSC profiles of phosphatidylcholine liposomes of various chain lengths, and EPR measurements of spin labelled liposomes demonstrated that the susceptible hydroxyl group of these compounds are located in the lipid region of the bilayer close to the double bonds of polyunsatured fatty acids, making these stilbenes particularly suitable for the prevention and control of the lipid peroxidation of the membranes.

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Structure–Property Relationships of Trimetazidine Derivatives and Model Compounds as Potential Antioxidants

Cited by 169 publications

References 41 publications

Genesis and development of DPPH method of antioxidant assay

Genesis and development of DPPH method of antioxidant assay

In vitroantioxidant activity of silymarin

Antioxidant properties of resveratrol and piceid on lipid peroxidation in micelles and monolamellar liposomes

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