Structure versus function in high myopia using optical coherence tomography and automated perimetry

Sharif, Nasrin Moghadas; Shoeibi, Nasser; Ehsaei, Asieh; Atchison, David A.

doi:10.1111/cxo.12836

Cited by 9 publications

(9 citation statements)

References 39 publications

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“…According to Moghadas et al, the decreased sensitivity of the VF examination in high myopia was related to the decrease in the thickness of the retinal layer. 58 Decrease in the thickness of the ganglion cell layer could be caused by stretching of the retina, and Wolsley et al explained that this reduction in thickness can be mainly divided into photoreceptor cells and the inner layer of the retina. 59 It is also confirmed that there is variation in macular thickness in patients with myopia, and such foveal depression and photoreceptor outer segment elongation may lead to decreased visual function.…”

Section: Discussionmentioning

confidence: 99%

Ocular and Hemodynamic Factors Contributing to the Central Visual Function in Glaucoma Patients With Myopia

Hong

Kim

Shin

et al. 2022

Invest. Ophthalmol. Vis. Sci.

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Purpose The purpose of this study was to investigate the ocular and hemodynamic factors contributing to the central visual function in glaucoma patients with myopia. Methods This study was a prospective observational study, which included 236 eyes of 140 patients with normal-tension glaucoma (NTG), which includes 114 eyes with mild myopia (axial length ≥24 and <26 mm) and 122 eyes with moderate-to-severe myopia (axial length ≥26 mm). Ocular characteristics were axial length and posterior pole profiles, including peripapillary atrophy (PPA) to disc area ratio, disc tilt ratio, disc torsion, and disc-foveal angle. Hemodynamic factors included standard deviation of the mean of qualified normal-to-normal intervals (SDNN) of a heart rate variability (HRV) test and vessel density (VD) parameters from optical coherence tomography angiography (OCTA). The root mean square error was estimated as a measure of the VD fluctuation. Association between ocular characteristics and VD parameters of the OCTA with the central sensitivity of the 10-degree visual field or the presence of central scotoma were analyzed. Results Deep layer VD of the peripapillary and macular areas showed significant differences between mild and moderate-to-severe myopia ( P = 0.034 and P = 0.045, respectively). Structural parameters, especially PPA to disc area ratio, had significant correlation with peripapillary VD parameters in myopic eyes. Lower SDNN value (ß = 0.924, P = 0.011), lower deep VD of the macular area (ß = 0.845, P = 0.001), and greater fluctuation of deep VD in the peripapillary area (ß = 1.517, P = 0.005) were associated with the presence of central scotoma in patients with glaucoma with myopia in multivariate logistic regression analysis. Conclusions The structural changes by myopia, especially in the peripapillary region, affected VD parameters in myopic eyes. Lower deep VD and greater VD fluctuation in the peripapillary region showed association with central scotoma in patients with glaucoma with myopia, suggesting both structural and vascular changes by myopia may be related to central visual function in glaucoma patients with myopia.

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Section: Discussionmentioning

confidence: 99%

Ocular and Hemodynamic Factors Contributing to the Central Visual Function in Glaucoma Patients With Myopia

Hong

Kim

Shin

et al. 2022

Invest. Ophthalmol. Vis. Sci.

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“…The wider temporal window in high myopia may be related to the changes in the retina. With the abnormal elongation of the globe, 4 high myopia is associated with a variety of anatomical changes in the retina, 10 , 44 – 46 which have been linked to retinal functional deficits, 5 , 9 , 44 , 47 – 50 such as the delayed mfERG responses 15 , 50 and decreased macular light sensitivity. 9 , 44 Park et al 46 reported that the photoreceptor layer thickness in the foveola significantly decreased with increasing myopia.…”

Section: Discussionmentioning

confidence: 99%

“…With the abnormal elongation of the globe, 4 high myopia is associated with a variety of anatomical changes in the retina, 10 , 44 – 46 which have been linked to retinal functional deficits, 5 , 9 , 44 , 47 – 50 such as the delayed mfERG responses 15 , 50 and decreased macular light sensitivity. 9 , 44 Park et al 46 reported that the photoreceptor layer thickness in the foveola significantly decreased with increasing myopia. Similarly, Wang et al 44 found that the thickness of the myoid and ellipsoid zone within 2° from the macular center was correlated with the axial length.…”

Section: Discussionmentioning

confidence: 99%

“…The spatial aspects of visual deficits in high myopia have been demostrated in many studies. 6 , 9 , 11 – 16 Living in a dynamic environment requires our visual system to process visual information over extended intervals of time to maintain a stable and reliable performance. 17 – 20 It has been reported recently that myopes showed significantly reduced performance when viewing dynamic stimuli.…”

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confidence: 99%

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Defective Temporal Window of the Foveal Visual Processing in High Myopia

Zheng

Ying

He³

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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To investigate the temporal characteristics of visual processing at the fovea and the periphery in high myopia. METHODS.Eighteen low (LM, ≤ −0.50 and > −6.00 D) and 18 high myopic (HM, ≤ −6.00 D) participants took part in this study. The contrast thresholds in an orientation discrimination task under various stimulus onset asynchrony (SOA) masking conditions were measured at the fovea and a more peripheral area (7°) for the two groups. An elaborated perceptual template model (ePTM) was fit to the behavioral data for each participant.RESULTS. An analysis of variance with three factors (SOA, degree of myopia and eccentricity) was performed on the threshold data. The interaction between SOA and degree of myopia in the fovea was significant (F (4, 128) = 2.66, P = 0.036), suggesting that the masking effect had different temporal patterns between the two groups. The temporal profiles for the two groups were derived based on the ePTM model. The peak and the spread of the temporal window in the fovea were much lower and wider, respectively, in the HM group than that in the LM group (both Ps < 0.05). There was no significant difference in the peripheral temporal window between the two groups. CONCLUSIONS.High myopia is associated with defective temporal processing in the fovea, captured by a flattened temporal window.

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“…High myopia is associated with significant long‐term risks of vision impairment, from pathologic conditions such as retinal detachment and glaucoma . Using OCT, Moghadas Sharif et al show that ganglion cell layer thinning may lead to visual field defects in highly myopic eyes, with these myopia‐related visual field losses possibly due to lateral retinal stretching.…”

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confidence: 99%

Optical coherence tomography: seeing the unseen

Bui

Downie

Lindsay

2019

Clinical and Experimental Optometry

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Structure versus function in high myopia using optical coherence tomography and automated perimetry

Abstract: The correlation between retinal layer thicknesses and visual field sensitivity could be explained by myopia-related losses due to lateral retinal stretching, with further research required to investigate this.

Cited by 9 publications

References 39 publications

Ocular and Hemodynamic Factors Contributing to the Central Visual Function in Glaucoma Patients With Myopia

Ocular and Hemodynamic Factors Contributing to the Central Visual Function in Glaucoma Patients With Myopia

Defective Temporal Window of the Foveal Visual Processing in High Myopia

Optical coherence tomography: seeing the unseen

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