Structures of bis(piperidine-1-dithiocarbamato)nickel(II) and bis(piperidine-1-dithiocarbamato)copper(II)

Akella, Radha; Seshasayee, M.; Aravamudan, G.

doi:10.1107/s0108270188003865

Cited by 15 publications

(4 citation statements)

References 7 publications

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“…5, was quite unexpected. { A search of single-crystal structures yielded a result identical to ours, 6 namely, bis(piperidine-1-dithiocarbamato) copper(II), the divalency of the copper causing the paramagnetism of the compound. The complexation of CS 2 ligands by Cu 2+ is easily explained, but the origin of our piperidine N-terminal ligands is not as clear.…”

supporting

confidence: 70%

A reassignment of the EPR spectra previously attributed to Cu@C60

et al. 2007

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supporting

confidence: 70%

A reassignment of the EPR spectra previously attributed to Cu@C60

et al. 2007

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“…The S1–Cu1–S2 1 , 77.22(2)° bite angle is significantly smaller than that of a perfect four coordinate Cu(II) in a square planar geometry [ 41 ]. The bond lengths of 2.3019(7) Å for Cu1–S1 and 2.3119(8) Å for Cu1–S2 are typical bond lengths of bis(dithiocarbamato)Cu(II) compounds in a square planar geometry [ 42 ]. The bond lengths and angles of the compound are similar to those of the reported Ni(II) morpholine dithiocarbamate complex [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Crystal Structures and Anticancer Studies of Morpholinyldithiocarbamato Cu(II) and Zn(II) Complexes

et al. 2020

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Cu(II) and Zn(II) morpholinyldithiocarbamato complexes, formulated as [Cu(MphDTC)2] and [Zn(μ-MphDTC)2(MphDTC)2], where MphDTC is morpholinyldithiocarbamate were synthesized and characterized by elemental analysis, spectroscopic techniques and single-crystal X-ray crystallography. The molecular structure of the Cu(II) complex revealed a mononuclear compound in which the Cu(II) ion was bonded to two morpholinyl dithiocarbamate ligands to form a four-coordinate distorted square planar geometry. The molecular structure of the Zn(II) complex was revealed to be dinuclear, and each metal ion was bonded to two morpholinyl dithiocarbamate bidentate anions, one acting as chelating ligand, the other as a bridge between the two Zn(II) ions. The anticancer activity of the morpholinyldithiocarbamate ligand, Cu(II) and Zn(II) complexes were evaluated against renal (TK10), melanoma (UACC62) and breast (MCF7) cancer cells by a Sulforhodamine B (SRB) assay. Morpholinyldithiocarbamate was more active than the standard drug parthenolide against renal and breast cancer cell lines, and [Zn(μ-MphDTC)2(MphDTC)2] was the most active complex against breast cancer. The copper(II) complex had a comparable activity with the standard against renal and breast cancer cell lines but showed an enhanced potency against melanoma when compared to parthenolide.

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“…[191 or C,H,,NCS; [20]). Apparently, the distance between the cyclic ring and the metal core in 1 or 2 is quite long and no mutual steric influence in the related bond parameters can be observed.…”

Section: Resultsmentioning

confidence: 99%