“…23 , 24 These analogs bind to tubulin leading to morphological changes and then disrupt tumor vasculature, and are in phase II trials. 25 , 26 Homoharringtonine ( 8 ), a cephalotaxus alkaloid from the tree, Cephalotaxus harringtonia found in mainland China, 27 is an inhibitor of protein synthesis and is reported to have activity against hematologic malignancies. 28 Ingenol 3-Oangelate ( 9 ), an analog of the polyhydroxy diterpenoid, ingenol, which was originally obtained from Euphorbia peplus (known as " petty spurge " in England or " radium weed " in Australia), is a potential topical chemotherapeutic agent for skin cancer and exhibits its action through activation of protein kinase C. 29 , 30 Phenoxodiol ( 10 ), a synthetic analog of daidzein, a well known isofl avone from soybean ( Glycine max ), is being developed as a therapy for cervical, ovarian, prostate, renal, and vaginal cancers, and induces apoptosis through inhibition of anti-apoptotic proteins including XIAP and FLIP.…”