Structures of two new flavonoids fromScutellaria ramosissima

Flavonoids in Scutellaria immaculata and S. ramosissima (Lamiaceae) and their biological activity

“…Flavonoids 14, 21 and 25 had been isolated before from the aerial and roots from this plant. [12][13][14]16] In this study we have recorded flavonoids 1, 8, 9, 11-14, 16, 18-20, 21-23, 25 and 26 from aerial parts of S. immaculata for the first time (Tables 1 and 2, and Figures 2 -4). The occurrence of flavonoids 14, 25, and 26 in S. immaculata is in agreement with the previously reported flavonoid profile.…”

“…Flavonoids 1 – 7 , 9 – 14 and 16 – 27 from aerial parts and 3 – 8 , 10 – 16 and 18 – 27 from roots were identified in S. ramosissima for the first time (Figures 2–4). Flavonoids 14 , 21 and 25 had been isolated before from the aerial and roots from this plant [12–14,16] …”

“…S. immaculata has been studied previously and 17 flavonoids (chrysin‐7‐ O ‐glucuronide, scutellarein‐7‐ O ‐glucoside, apigenin‐7‐ O ‐glucoside, baicalein‐7‐ O ‐glucoside, norwogonin‐7‐ O ‐glucoside, oroxyloside, wogonoside, immaculoside, 5,2′‐dihydroxy‐6,7,6′‐trimethoxyflavanone, 5,2′‐dihydroxy‐6,7,8,6′‐tetramethoxyflavanone, chrysin, wogonin, apigenin, isoscutellarein, scutellarein, cosmosiin (apigenin‐7‐ O‐β ‐ d ‐glucopyranoside), and wogonin‐7‐O‐ β ‐ d ‐glucopyranoside) were identified; [15,16] and from S. ramosissima , chrysin 7‐ O‐β ‐ d ‐glucuronide, 2(S)‐2′,5,7‐trihydroxyflavanone 7‐ O ‐(Me β ‐ d ‐glucopyranosiduronate), 2(S)‐2′,5,7‐trihydroxyflavanone 7‐ O ‐(Et β ‐ d ‐glucopyranosiduronate), 5,2′‐dihydroxy‐7‐ O‐β ‐ d ‐glucopyranosylflavone, rivularin, 5,2′‐dihydroxy‐7‐ O ‐ β ‐ d ‐glucopyranosylflavanone, oroxylin A, wogonin, norwogonin, 5,2′,6′‐trihydroxy‐6,7,8‐trimethoxyflavone, and 5,6‐dihydroxy‐7,8‐dimethoxyflavone [12,13,23] . However, flavonoids have not been determined fully in S. immaculata and S. ramosissima .…”

“…are perennial shrubs that grow in Northern Tien Shan, Pamirs and Altay mountains (Central Asia). Chemical analysis of these plants indicate the presence of flavonoids [12–16] . Although, there are widespread reports about the anti‐tumour, antibacterial and antioxidant effects of some species of this genus, in‐vitro biological studies have not yet been conducted on S. immaculata and S. ramosissima .…”

New flavanones from Scutellaria phyllostachya roots

“…The solid was diluted with water and extracted successively by shaking with hydrocarbons, CHCl 3 , EtOAc, and n-BuOH. Chromatography of the CHCl 3 fraction over a column of silica gel using a gradient of CHCl 3 :hydrocarbons isolated the known flavonoids chrysin (5,7-dihydroxyflavone) [2,3], wogonin (5,7-dihydroxy-8-methoxyflavone) [3,4], and norwogonin (5,7,8-trihydroxyflavone) [3,5] and flavonoids 1 and 2. We previously isolated from S. comosa Juz.…”