Strumal Carcinoid Tumor of the Ovary: A Case Exhibiting Severe Constipation Associated with PYY

Matsuda, Kyoko; Maehama, Toshiyuki; Kanazawa, Kazuki

doi:10.1006/gyno.2002.6785

Cited by 42 publications

(28 citation statements)

References 6 publications

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“…Like hindgut carcinoids, but unlike the primary ovarian insular carcinoid, SCTO is not, as a rule, associated with carcinoid syndrome and usually not accompanied with any specific clinical findings . However, there are some reports of SCTO complicated by severe constipation associated with PYY and hyperinsulinemic hypoglycemia with melanosis as one symptom or a symptom apart from the carcinoid syndrome . The potential for the occurrence of a thyroid‐type papillary carcinoma in SCTO has also been reported …”

Section: Discussionmentioning

confidence: 99%

Cytopathologic characteristics of the primary strumal carcinoid tumor of the ovary: A case report with emphasis on differential diagnostic considerations

Hayashi

Haba

Kushida

et al. 2011

Diagnostic Cytopathology

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Primary strumal carcinoid tumor of the ovary (SCTO) is an extremely rare entity, though the survival rate is excellent if the disease is confined to one ovary. A case is presented here in which intraoperative squash smears in a 45-year-old woman with a left adnexal mass revealed dispersed or small clusters of neoplastic cells forming loosely cohesive gland-like structures with abundant cytoplasm. The nuclear chromatin was finely granular with a "salt and pepper" appearance and occasional tiny nucleoli. The position of the nucleus presented a vaguely plasmacytoid appearance. Small fragments of thyroidal colloid-like structures were also identified. A cytopathologic diagnosis of a SCTO was suggested. Further evaluation and immunohistochemical studies were conducted on formalin-fixed, paraffin-embedded material. Cords or nests of uniform cells with abundant cytoplasm, and eccentric nuclei with coarse chromatin and occasional colloidal tissue were identified on H&E sections. The tumor cells showed diffuse and strong cytoplasmic staining for chromogranin A, synaptophysin, CD56, and vimentin but were negative for calretinin, α-inhibin or CDX2. The proliferative index with MIB-1 was around 3%. Thyroidal colloid-like structures were immunoreactive for thyroglobulin and TTF-1 stains. The diagnosis of primary SCTO was confirmed based on cytopathologic, histopathological, and immunohistochemical results, and the location of the tumor. Awareness of the cytopathological findings of SCTO can assist in diagnosing this rare entity correctly.

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Section: Discussionmentioning

confidence: 99%

Cytopathologic characteristics of the primary strumal carcinoid tumor of the ovary: A case report with emphasis on differential diagnostic considerations

Hayashi

Haba

Kushida

et al. 2011

Diagnostic Cytopathology

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“…[1][2][3] Some trabecular or strumal carcinoid tumors may produce peptide YY, which inhibits intestinal mobility and causes chronic constipation. [1][2][3]10 The tumor in our Case 2 showed estrogenic activity. Various ovarian tumors with estrogenic manifestations attributable to functioning stroma have been reported.…”

Section: Discussionmentioning

confidence: 99%

Primary Carcinoid Tumor of the Ovary: MR Imaging Characteristics with Pathologic Correlation

Takeuchi

Matsuzaki

Uehara

2011

MRMS

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Ovarian carcinoid tumor is a rare neoplasm that may appear as a solid mass or often combined with teratomas or mucinous tumors. We report 2 cases associated with mucinous cystadenomas and describe their magnetic resonance imaging characteristics. On T 2 -weighted images, the tumors appeared as multilocular cystic masses with hypointense solid components as a result of abundantˆbrous stroma induced by serotonin. Demonstration of prominent hypervascularity of the tumors following contrast administration on dynamic study may be the clue to diŠerential diagnosis.

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“…Matsuda et al reported that a 50-year-old woman experienced constipation again 10 months after resection of a stage Ia strumal carcinoid tumor and showed recurrence (10). We believe serum PYY might be used as a tumor marker in the diagnosis and monitoring of this distinctive hormone producing tumors, especially when the symptom is severe constipation rather than diarrhea or flushing.…”

Section: Discussionmentioning

confidence: 99%

Ovarian strumal carcinoid presenting as severe progressive constipation

Kachhawa

Kumar

Singh

et al. 2011

Journal of Surgical Case Reports

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Strumal carcinoid develops in a germ cell tumor characterized by an intimate mixture of thyroid and carcinoid. Unlike other carcinoid tumors, most patients with strumal carcinoid have no symptoms of carcinoid syndrome; few are reported to cause severe constipation.We report a case of a 60-year-old female patient presenting with severe progressive constipation and painful defecation for last few years. A right ovarian tumor was discovered during clinical examination. CT scan revealed a large lobulated solid cystic right adenexal mass suggestive of monomorphic teratoma, which was successfully removed surgically. The histopathology confirmed the diagnosis of strumal carcinoid tumor. Her constipation completely disappeared post surgery. These tumors are known to produce a biologically active substance like peptide YY, which has a pharmacologic inhibitory action on intestinal motility. This was presumably the cause of the constipation in this patient rather than a mechanical effect of the tumor.

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Strumal Carcinoid Tumor of the Ovary: A Case Exhibiting Severe Constipation Associated with PYY

Cited by 42 publications

References 6 publications

Cytopathologic characteristics of the primary strumal carcinoid tumor of the ovary: A case report with emphasis on differential diagnostic considerations

Cytopathologic characteristics of the primary strumal carcinoid tumor of the ovary: A case report with emphasis on differential diagnostic considerations

Primary Carcinoid Tumor of the Ovary: MR Imaging Characteristics with Pathologic Correlation

Ovarian strumal carcinoid presenting as severe progressive constipation

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