Strychnine poisoning

Application of solid phase microextraction to the determination of strychnine in blood

“…There is very little protein binding [4], and its distribution to tissues is rapid. The major route for removal and detoxification is hepatic metabolism [5], via enzymatic degradation involving the liver microsomal system, and up to 20% of the drug can be excreted unchanged in the urine [4]. Soon after ingestion, violent and generalized convulsions take place, and when death occurs, it is commonly due to asphyxia from respiratory arrest during convulsions [6].…”

Water Hemlock (Cicuta Douglasii) Toxicoses in Sheep: Pathologic Description and Prevention of Lesions and Death

“…Excess motor neuron or sympathetic stimulation causing myonecrosis has been observed in strychnine or cocaine intoxication or in cases of severe physical exertion. 3,10,14 The toxicant, cicutoxin, is a long-chain highly unsaturated diol.…”

Glycine decarboxylase deficiency–induced motor dysfunction in zebrafish is rescued by counterbalancing glycine synaptic level

“…Here we propose that agonizing GlyT1 activity may have a broader action in the brain by counterbalancing hyperglycinemia at both the glycinergic and glutamatergic/NMDA synapse. However, the attenuation of glycine signaling in the brain can have important side effects that have to be considered, as exemplified by the poisoning effect of strychnine, a potent glycine receptor antagonist (24). As a result, such a therapeutic strategy would require the design and development of GlyT1 agonists with varying potency, whose activity could be efficiently adjusted to each GE patients.…”