This research is aimed to explore gender differences in children’s school dropout due insecurity and harassment in and on the way to school in Sindh. The research is designed as a quantitative research. A survey of 5641 school dropout children in Sindh is done with the help of a questionnaire developed by the researcher. The results of the research show that more than 10% of the children have reported that insecurity on the way from home to school is a cause of their school dropout. The result of t-test shows that more girls than boys are reporting to have left school due to insecurity or harassment they are facing either in school or on the way to school.