21st Century Skills are studied by many institutions and organizations around the world. In this context, Turkey has established the Turkish Qualifications Framework and determined 8 Key Competencies for high schools. In this study, the status of high school students having 8 Key Competencies was investigated. The research was carried out with the relational screening method. The data of the study were collected from 1089 secondary school students studying in a province in the south of Turkey. T-test, ANOVA, correlation analysis and SEM analysis were applied to the findings obtained from the research. According to the results of the research, there are significant differences between the variables. In addition, relations between the variables were determined and SEM was established.