Studies in the Chemistry of Some New 1,2,4-thiadiazolidine by Oxidative Cyclisation

Abstract

Recently in this laboratory a novel series of Hector's bases (1, 2, 4-thiadiazolidine) had been synthesised. 1-substituted-3-formamidinothiocarbamides (1a-f) and 1,3-bis(N-substituted-thioamido)guanidines (1g-l) were oxidatively cyclised by using aqueous bromine as oxidizing agent in chloroform medium to synthesised yet new series of Hectors bases, viz; 3-imino-5-substituted imino-1,2,4-thiadiazolidine (2a-f) and 3-substituted thioamidoimino-5-substitutedimino-1,2,4-thiadiazolidine (2g-l), respectively The oxidative cyclisation of (1a-l) was also carried out by making use of H 2 O 2 in concentrated HCl as the oxidizing agent. The Hector's bases isolated in these reactions were characterised on the basis of conventional elemental analysis, chemical characteristics and IR and 1 H-NMR spectral analysis.

Synthesis of 2-(N-Substituted)Thiocarbamido-5-(N-Substituted)-2,4-Dithiobiurato)-1,3 Benzothiazoles and Antimalarial Activity

“…Thiobiuret analogues had been reported as analgesic 7 , anti-convulsant and hypnotic properties 8 .Glycosylatedbiuret is used as glycoenzyme inhibitors 9 . Successive cyclisation of 2,4-dithiobiurate gave formation of five or six member heterocycles and showed medicinal, agricultural and pharmaceutical applications [10][11][12][13][14] . The synthesized heteroacycles are used as a best intermediated in the synthesis of thiadiazoles, dithiazoles, thiadizines, triazines, Hector's bases etc.…”

Synthesis and Antimicrobial Activities of N-(7-Substitutedthio Carbamidoquinoline-4-Yl)-N, N-Diethyl-Pentane-1, 4-Diamine

“…As evident from structure of N-(7substitutedthiocarbamidoquinoline-4-yl)-N,N-diethylpentane-1,4-diamine possesses Chloro, amino, methyl and ethyl reactive sides for various reactions. As a wider porgramme of this laboratory in the synthesis of nitrogen, sulphur and nitrogen and sulphur containing heteroacycles and heterocycles the interactions of cynoguanidine with various thiourea and isothiocyanates had been investigated in sufficient details [2][3][4][5][6][7][8] . Some of these compounds showed remarkable pharmaceutical and biological activities [9][10][11][12] .…”

A Novel Synthesis and Antimicrobial Studies of 3-(4-Substitutedthiocarbamidophenyl)-N, N-dimethyl-3-Pyridin-2-yl-propan-1-amine

“…IR spectra were recorded on Perkin Elmer Spectrometer in range 4000-400 cm -1 in KBr pellets. PMR spectra were recorded on Bruckner Ac 300 F Spectrometer with TMS as internal standard using CDCl 3 and DMSO-d 6 as solvent. The purity of compound was checked on silica Gel-G Pellets by TLC with layer thickness of 0.3 mm.…”

“…As evident from structure of 3-(4-substituted thiocarbamidophenyl)-N, N-dimethyl-3-pyridin-2-yl-propan-1-amine, it possesses chloro, amino, methyl and ethyl reactive sites for various reactions. As a wider programmee of this laboratory in the synthesis of nitrogen, sulphur and nitrogen and sulphur containing heteroacycles and heterocycles the interactions of cynoguanidine with various thiourea and isothiocynates have been investigated in sufficient details [2][3][4][5][6][7][8] .…”

“…An exhaustive literature survey on thiocarbamids [3][4][5][6] and 3-(4-substituted thiocarbamido phenyl)-N, N-dimethyl-3-pyridin-2-yl-propan-1-amine [13][14][15] showed that these nucleus containing drugs play an important role in pharmaceutical, medicinal and drug chemistry having remarkable pharmaceutical, medicinal and biochemical applications, by considering all these facts into considerations interactions of 3-(4-chlorophenyl)-N, N-dimethyl-3-pyridin-2-yl-propan-1-amine with various thiourea in isopropanol medium were investigated to isolate yet new series of 3-(4-substitutedthiocarbamidophenyl)-N,Ndimethyl-3-pyridin-2-yl-propan-1-amine. (Scheme 1) For investigating the medicinal and pharmaceutical applications, the antimicrobial activities of synthesized compounds were studied.…”