Abstract:The drug delivery systems using biodegradable natural polymeric particles are becoming a clinical reality with many benefits for the patient. The versatility of polymeric materials allows the fabrication of the delivery device with desirable degree of swelling, and drug release. Alginate is a natural biopolymer which forms a hydrogel in the presence of divalent cations like Ca 2ϩ . 1,2) The inert environment within the biopolymer network of alginates allows for the entrapment of a wide range of bioactive subst… Show more
“…Among all the prepared formulations, the maximum drug loading and encapsulation efficiency was 19.5% and 61% that was gained by the highest paclitaxel to alginate mass ratio (0.5) and the highest external oil phase volume (5 ml). These findings are in agreement with the results of other researchers who studied the effect of drug to polymer mass ratio, external oil phase volume and CaCl 2 to alginate mass ratios in production of microparticles using alginate [26,[54][55][56][57][58][59][60]. Increasing 67% in paclitaxel to alginate ratio or 150% in external oil phase volume could enhance the drug loading and encapsulation efficiency in all formulations.…”
Section: Morphology and Microparticle Sizesupporting
“…Among all the prepared formulations, the maximum drug loading and encapsulation efficiency was 19.5% and 61% that was gained by the highest paclitaxel to alginate mass ratio (0.5) and the highest external oil phase volume (5 ml). These findings are in agreement with the results of other researchers who studied the effect of drug to polymer mass ratio, external oil phase volume and CaCl 2 to alginate mass ratios in production of microparticles using alginate [26,[54][55][56][57][58][59][60]. Increasing 67% in paclitaxel to alginate ratio or 150% in external oil phase volume could enhance the drug loading and encapsulation efficiency in all formulations.…”
Section: Morphology and Microparticle Sizesupporting
“…The method used for this part of experiment was adopted from Basu and Rajendran (2008) with some modification. Calcium chloride-alginate encapsulating microcapsule network collected from the o/w emulsion containing calcium chloride solution was dried at 70 • C for one day.…”
Section: Calcium Contents Of Alginate Network In Bulk Emulsion and Almentioning
“…The spectra were recorded for pure drug and drug-loaded microbeads. Individual beads were crushed in pestle and mortar and then mixed 1 mg of crushed material with 100 mg of KBr (Merk IR Spectroscopy grade) and dried at 40 o C. Then FT-IR spectra of the scanning wavelength range 4000-400cm -1 were recorded by using a FT-IR spectrophotometer (IR-Prestige-21, Shimadzu, Japan) [13].…”
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