Studies, in the Rat, of Susceptibility To Dental Caries I. Bacteriological and Nutritional Factors1

Rosebury, Theodor; Karshan, Maxwell

doi:10.1177/00220345310110010201

Cited by 14 publications

(3 citation statements)

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“…On deficient diets the teeth having caries also show the characteristic evidences of defective calcification (figs. 6,8,12,13,14). Conversely, it may hardly be necessary to point out that teeth may be calcified equally poorly without showing caries .…”

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“…Shibata's description appears to correspond more closely to dental caries in man than cusp lesions in a region that has no true analogue in human teeth. In view of our previous unsuccessful attempts to produce dental caries in rats (8,9), it appeared advisable to repeat Shibata's work in an effort to determine whether the rat is susceptible to a type of dental caries comparable to that of man. The successful accomplishment of this objective has opened a promising new field for investigation into the etiology of the lesion.…”

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Studies, in the Rat, of Susceptibility to Dental Caries

1933

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EXPERIMENTAL Shibata states that he reared young rats on a diet consisting of "whole" rice and greens, plus 5-10 percent of various carbohydrates, of which dextrin and maltose were most effective in producing caries. The lesion, he states, developed in the molar fissures in about twenty days, and destroyed the crown in a week. Our first experiment was an attempt to repeat this finding. The animals were the Long-Evans strain of hooded rats, originally given to us in March, 1930, by Prof. P. E. Smith of the Department of Anatomy, and since bred by ourselves on a modified McCollum stock-ration (9). Full litters were distributed among the experimental groups in all cases at weaning, twenty-two days after birth. All animals were weighed every five days. Diets, other than spinach, were fed ad lib.Group I. Four litters, comprising 22 animals, were placed on Diet 1: Brown rice ("Comet"), unground, 92 (percent); white-potato dextrin, 8;

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Studies, in the Rat, of Susceptibility to Dental Caries

1933

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“…Using 2 dogs, Fehr (10) in 1862 was one of the first to sense the value of using experimental extirpation of the salivary glands as a means of studying their activities. Because comparative studies on operative physiology (11), type of secretion (12), enzymatic action (13), and histology (14, 15) between the salivary glands of man and the rat have indicated a marked similarity, and because the animal has been so well studied, even in its dental aspects (16,17,18,19,20), the albino rat (Mus norvegicus albinus) was chosen as the experimental animal for the studies of the salivary glands and the development of a technique for their surgical removal.…”

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A Description of the Salivary Glands of the Rat and a Procedure for Their Extirpation 1,2

Cheyne

1939

J Dent Res

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The possibility that the salivary glands have functions in addition to those of aiding deglutition and digestion of food has never been satisfactorily investigated. The only evidence of auxiliary salivary functions consists of occasional reports in the literature claiming increased dental caries (1), effects on blood pressure (2), change in glucose tolerance (3, 4), reduction in dental calcification (5), and variations in the gastric secretions (6,7,8,9) due to absence of the normal salivary secretion. Oral manifestations reported are difficulty in mastication and articulation, dry and atrophic oral mucous membranes, fissured tongue, retention of food debris and, in all cases, the necessity of taking considerable amounts of water with the food.Using 2 dogs, Fehr (10) in 1862 was one of the first to sense the value of using experimental extirpation of the salivary glands as a means of studying their activities. Because comparative studies on operative physiology (11), type of secretion (12), enzymatic action (13), and histology (14, 15) between the salivary glands of man and the rat have indicated a marked similarity, and because the animal has been so well studied, even in its dental aspects (16,17,18,19,20), the albino rat (Mus norvegicus albinus) was chosen as the experimental animal for the studies of the salivary glands and the development of a technique for their surgical removal.For convenience and simplicity of presentation, it seems best, first, to give a summary of the nature and anatomical distribution of the 1 The study upon which this report is based was made possible by funds granted by the Carnegie Corporation of New York.

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