Studies in the Use of the Intraperitoneal Route for Parenteral Nutrition in the Rat

LeLeiko, Neal S.; Bronstein, A.D.; Murphy, Jonathan; Fox, James G.; Lieberman, Kenneth V.

doi:10.1177/0148607183007004381

Cited by 7 publications

(2 citation statements)

References 6 publications

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“…The ability of the peritoneum to absorb fluids and salts is extensively used in dialysed patients. Studies on animals (4,5,9) showed that the peritoneal cavity may also serve as a route for the administration of nutrients. Dextrose and amino acid solutions were found to be highly absorbable by the peritoneum.…”

Section: Discussionmentioning

confidence: 99%

Successful Intraperitoneal Nutrition in Rabbits with Short-Bowel Syndrome

Erez

Gutermacher²,

Kariv³

et al. 2001

Eur J Pediatr Surg

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The efficacy of intraperitoneal alimentation as a means of nutritional support for various degrees of short-bowel syndrome was studied, using the rabbit model. Twenty-eight rabbits were divided into 5 groups. Group I had a sham operation; Groups II, III and IV had 50 %, 75 % and 90 % small-bowel resections (SBR), respectively; Group V had a 90 % SBR with intraperitoneal nutrition. All the rabbits received a regular diet and tap water post-operatively. The rabbits in Group V received intraperitoneal alimentation (IPA) by way of a peritoneal catheter inserted at the time of surgery. The nutrition consisted of 10 % dextrose with 5.5 % amino acids. This provided 30 - 35 kcal/kg of additional energy per day. All the rabbits within Group IV (90 % resection without IP nutrition) died within 2 to 5 weeks. IP nutrition enabled body weight to be maintained and prevented the death of all rabbits with 90 % small-bowel resection.

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Section: Discussionmentioning

confidence: 99%

Successful Intraperitoneal Nutrition in Rabbits with Short-Bowel Syndrome

Erez

Gutermacher²,

Kariv³

et al. 2001

Eur J Pediatr Surg

View full text Add to dashboard Cite

show abstract

“…Intraperitoneal delivery in animals provides a relatively simple and efficient route to study parenteral nutrition in humans. 96 In HAR, mouse pups received L-leucine (1.5 μg/g, Sigma, L6914), or L-isoleucine (0.6 μg/g, Sigma, I5281), or L-valine (2.4 μg/g, Sigma, V4638) from P7 to P9. The dose was estimated based on circulating levels of these amino acids in mice: L-leucine (∼200μM), 97 L-isoleucine (80-100μM), 97 , 98 and L-valine (200-400μM).…”

Section: Methodsmentioning

confidence: 99%