Studies of Antimutagenic Effects of Vitamins A and C in Humans

Abasova, O. Yu.; Reutova, N. V.; Сычева, Л. П.; Чернышева, Е. А.

doi:10.1007/s10517-013-2022-7

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…Similar scenarios have also been observed for deficiencies in vitamin B-12, riboflavin, vitamin A, and minerals such as calcium and zinc (99). Conversely, supplementation with folic acid (97, 100-108), riboflavin, pantothenic acid, biotin (4), cobalamin (93,103), vitamin C (109)(110)(111)(112)(113)(114)(115), vitamin E (114), and vitamin A and its derivatives (107,112) was associated with decreased genotoxic damage and micronucleus reduction (4). Much research has been conducted to show the effects of folic acid supplementation and folate status on reduced micronucleus frequency.…”

Section: Micronutrients and Chromatin Instabilitymentioning

confidence: 58%

Epigenetic Regulation of Centromere Chromatin Stability by Dietary and Environmental Factors

Hernández-Saavedra

Strakovsky

Ostrosky‐Wegman

et al. 2017

Advances in Nutrition

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The centromere is a genomic locus required for the segregation of the chromosomes during cell division. This chromosomal region together with pericentromeres has been found to be susceptible to damage, and thus the perturbation of the centromere could lead to the development of aneuploidic events. Metabolic abnormalities that underlie the generation of cancer include inflammation, oxidative stress, cell cycle deregulation, and numerous others. The micronucleus assay, an early clinical marker of cancer, has been shown to provide a reliable measure of genotoxic damage that may signal cancer initiation. In the current review, we will discuss the events that lead to micronucleus formation and centromeric and pericentromeric chromatin instability, as well transcripts emanating from these regions, which were previously thought to be inactive. Studies were selected in PubMed if they reported the effects of nutritional status (macro- and micronutrients) or environmental toxicant exposure on micronucleus frequency or any other chromosomal abnormality in humans, animals, or cell models. Mounting evidence from epidemiologic, environmental, and nutritional studies provides a novel perspective on the origination of aneuploidic events. Although substantial evidence exists describing the role that nutritional status and environmental toxicants have on the generation of micronuclei and other nuclear aberrations, limited information is available to describe the importance of macro- and micronutrients on centromeric and pericentromeric chromatin stability. Moving forward, studies that specifically address the direct link between nutritional status, excess, or deficiency and the epigenetic regulation of the centromere will provide much needed insight into the nutritional and environmental regulation of this chromosomal region and the initiation of aneuploidy.

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Section: Micronutrients and Chromatin Instabilitymentioning

confidence: 58%

Epigenetic Regulation of Centromere Chromatin Stability by Dietary and Environmental Factors

Hernández-Saavedra

Strakovsky

Ostrosky‐Wegman

et al. 2017

Advances in Nutrition

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“…Persimmon fruits contain vitamins C and B, trace elements zinc, copper, iron, chromium, etc. These biogenic compounds and che mical elements, as well as some other compounds (some polypeptides) can have antimutagenic effect [1,5] mainly due to their antioxidant properties [10,11]. It is these substances in complex form that provide the antimutagenic activity of the composition of these extracts.…”

Section: Resultsmentioning

confidence: 99%

Antimutagenic Effects of the Composition from Green Tea Leaves Extracts and Caucasian Persimmon Fruits

Huseynov

Абдуллаев

2021

Bull Exp Biol Med

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On a culture of human peripheral blood lymphocytes, antimutagenic activity of a composition from extracts of green tea leaves and Caucasian persimmon fruits was established with a modification of the mutation process induced by chemical compounds producing an alkylating effect (nitrosomethylurea and sodium fluoride). A concentration dependence of the antimutagenic efficiency of the studied phytocomposite was shown. The highest antimutagenic efficiency was observed when a combination of green tea extract at a concentration of 0.01 μg/ml and persimmon fruit extract at a concentration of 0.001 μg/ml were used. Moreover, this combination was most effective against mutations induced by both nitrosomethylurea and sodium fluoride: the antimutagen efficiency factor was 0.53 and 0.55, respectively.

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“…Abasova et al 30 relataram, em recente publicação, os efeitos antimutagênicos da suplementação vitamínica, principalmente A e C, em humanos. Em nossa casuística, observamos que entre os que faziam uso de suplementação vitamínica, houve redução da ocorrência de picnose.…”

Section: Grupo De Influênciaunclassified

Frequência de micronucleação e outras alterações nucleares em células da mucosa bucal de pacientes anêmicos

Tomaz

Ferri

Filho

2016

Rev. Fac. Ciênc. Méd. Sorocaba

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RESUMOIntrodução: O Teste Citogenético do Micronúcleo é um biomarcador que fornece informações para avaliar lesões cromossômicas oriundas de ações genotóxicas. A frequência de micronúcleos pode ser mensurada em situações de exposição a ambiente e substâncias com alto poder genotóxico. Muitas anemias apresentam sua gênese na deficiência nutricional e têm como consequência o aumento das lesões no DNA, assim como estresse oxidativo elevado. Ácido fólico e vitamina B12 determinam maior instabilidade cromossômica, seja pela carência de cofatores ou por lesões oxidativas no material genético, com implicações para o sistema de reparo do DNA. Objetivos: Considerando a correlação entre as anemias e os danos ao material genético, objetivou-se no presente estudo avaliar a frequência de micronucleação e de outras alterações nucleares em células da mucosa bucal de adultos anêmicos. Métodos: estudo conduzido com 60 indivíduos, dos quais 30 eram anêmicos e 30 compunham o grupo controle. As amostras foram colhidas e processadas conforme protocolo preestabelecido, e as lâminas confeccionadas foram avaliadas microscopicamente para os critérios de proliferação, de genotoxicidade, de citotoxicidade e de morte celular. Para análise estatística, os testes t de Student, de Levene, de correlação de Pearson, e teste de Shapiro-Wilk foram utilizados para a correlação das variáveis. Resultados: A frequência de micronucleação e de outras alterações nucleares foram maiores em anêmicos, enquanto o grupo controle apresentou maior capacidade proliferativa. Além disso, os hábitos de vida também influíram nos critérios celulares avaliados. Conclusões: A elevada frequência de micronúcleos em anêmicos foi atribuída ao estresse oxidativo, ao déficit nutricional ou a outras condições predisponentes, como a etiologia genética da anemia ou a presença de doença crônica. Palavras-chave: anemia; genotoxicidade; testes para micronúcleos. ABSTRACT Introduction:The Micronucleus Cytogenetic Test is a biomarker that provides information to assess chromosomal damage which arises from genotoxic actions. The micronucleus frequency can be measured at situations of substances and environmental exposure with high genotoxic power. Many anemias have their genesis in nutritional deficiencies and have the consequence of an increment in DNA lesions, altogether with high oxidative stress. Folic acid and B12 vitamin determines more chromosomal instability, such cofactors deficiency or oxidative lesions in genetic material, with implications in DNA repair system. Objectives: Considering the correlation of the anemias and damage to genetic material, the present study aims to evaluate the micronucleation rate and other nuclei alterations in oral mucosal cells of anemic adults. Methods: This study was conducted with 60 patients, 30 of them were anemic and 30 were in the control group. The samples were collected and processed according to a pre-established protocol and thereafter slides were microscopically evaluated for proliferation, genotoxicity, cytotoxicity and cell death...

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Studies of Antimutagenic Effects of Vitamins A and C in Humans

Cited by 6 publications

References 6 publications

Epigenetic Regulation of Centromere Chromatin Stability by Dietary and Environmental Factors

Epigenetic Regulation of Centromere Chromatin Stability by Dietary and Environmental Factors

Antimutagenic Effects of the Composition from Green Tea Leaves Extracts and Caucasian Persimmon Fruits

Frequência de micronucleação e outras alterações nucleares em células da mucosa bucal de pacientes anêmicos

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