Studies of arteriosclerosis in japanese and american men

Abstract

A B S T R A C T The proportions of fatty acids in lipids of subcutaneous adipose tissue was compared in closely age-matched, urban men from two populations with a great difference in mortality from arteriosclerosis, namely in 50 Americans and 56 Japanese aged 15-65 yr who had died suddenly and unexpectedly. Specimens from both groups were analyzed side by side for fatty acids by gas-liquid chromatography. Compared with Japanese, Americans had significantly (P < 0.01) higher proportions of lauric (+ 0.2%), myristic (+ 0.4%), palmitic (+ 1.4%), stearic (+ 2.2%), and oleic (+ 5.3%) and lesser of palmitoleic (-1.8%), linoleic (-6.3%), and linolenic (-0.4%) acids. Japanese had higher proportions of longer chain polyunsaturated fatty acids. The distributions of fatty acids for the groups at ages 35-44 yr had significant differences. With age, Americans showed significant increases of palmitic and oleic acids and decreases of lauric, myristic, stearic, and linoleic acids; Japanese showed no correlations of proportions of fatty acids with age. The significant correlations between per cent standard body weight and fatty acids in Americans were positive for palmitic and negative for lauric and stearic

The Role of Site-Specific Adipose Tissue Fatty Acid Composition in Obesity

“…The adipose tissue profile shown in Fig. 41.2 is similar but not identical to those described in other countries and populations, such as Americans or Japanese [15], thus providing evidence for the greater influence of dietary contribution over endogenous metabolism on the fatty acid composition of adipose tissue.…”

“…These populations are well known for the high consumption of olive oil in their diets [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. In other populations, it has been demonstrated that the consumption of coconut oil increases the adipose tissue content of lauric and myristic acids, both SFAs [29], and adipose tissue samples from Japanese populations presented elevated proportions of PUFAs of the n-3 family such as eicosapentaenoic (EPA; C20:5n-3) and docosahexaenoic (DHA; C22:6n-3) acids, which were associated with high fish intake [15]. When vegetarians and nonvegetarians were compared, the former had higher proportions of linoleic acid in their adipose tissues, and were also believed to have higher PUFA intakes [30].…”

“…For example, the presence of lauric, myristic, stearic, and linoleic acids in the diet normally exceeds that in adipose tissue; in contrast, palmitoleic and oleic acids are more abundant in tissue than in the diet [15]. In addition, if PUFA consumption exceeds 30% of total dietary fat, this will not be translated into adipose tissue fatty acid profile, indicating that the diet has a limited ability to affect adipose tissue composition [41].…”

Comparison of dimension reduction methods on fatty acids food source study

“…The common point of those FAs source is their exogenous source, which confirmed us that TG + PL variables in IC 4 can reflect the exogenous FAs. To specify the sources of exogenous FAs, we calculated the correlation coefficients between loading values of TG + PL variables and reported adipose FA composition for Japanese, which is low ( ) 30 . Therefore, we refused the assumption that IC 4 reflects the adipose composition but accepted the suppose that IC 4 represents exogenous FAs.…”

Use of in vivo magnetic resonance spectroscopy for studying metabolic diseases

“…Some previous publications noted that saturated and unsaturated fats can have a different impact on metabolism 9 and are potentially related to cardiac disorders. 10 , 11 , 12 Thus, noninvasive assessments of fat composition by MRS could also become a powerful tool in relevant research. In tissues where lipid concentrations are very high, such as in bone marrow, fat compositional analysis by 1 H MRS can be powerful.…”