Studies of cardiopulmonary bypass in children: implications for the regulation of brain natriuretic peptide

Ationu, A; Singer, Donald R. J.; Smith, A. F.; Elliott, Martin J.; Burch, Michael; Carter, Nicholas D.

doi:10.1093/cvr/27.8.1538

Cited by 45 publications

(28 citation statements)

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“…In our patients, BNP levels were not significantly different immediately after surgery compared to preoperative values, and the highest BNP plasma concentration was measured on average 1.3 days after surgery. In contrast, a single report described lower BNP plasma levels after cardiac surgery in nine children compared to preoperative BNP plasma concentration [27]. However, BNP was measured only within 12 to 24 h after surgery.…”

Section: Discussionmentioning

confidence: 68%

Impact of cardiac surgery on plasma levels of B-type natriuretic peptide in children with congenital heart disease

Koch

Kitzsteiner

Zink

et al. 2007

International Journal of Cardiology

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Section: Discussionmentioning

confidence: 68%

Impact of cardiac surgery on plasma levels of B-type natriuretic peptide in children with congenital heart disease

Koch

Kitzsteiner

Zink

et al. 2007

International Journal of Cardiology

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“…This study was designed to provide insights into BNP in patients with CAD undergoing CABG, in view of the fact that up to now practically no results whatsoever have been available [7,8,9]. For this reason, we started by selecting short time intervals between BNP measurements in order to precisely identify the changes of BNP during the whole course of cardiac surgery.…”

Section: Discussionmentioning

confidence: 99%

Brain Natriuretic Peptide (BNP) in Patients Undergoing Coronary Artery Bypass Grafting

Bail

Kofler²,

Ziemer³

2004

Thorac cardiovasc Surg

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Surgical treatment of aortic regurgitation due to Behçet's disease is difficult. A 57-year-old male with Behçet's disease underwent aortic valve replacement with a mechanical valve for aortic regurgitation in 1995. Due to prosthetic valve detachment, 5 months thereafter he underwent a Bentall type operation with a composite graft. Due to complication of the left ventricle to pulmonary arterial fistula, 6 months later a third operation was performed for closure of the fistula. He is doing well at present 5 years after the third operation. Left ventricle to pulmonary arterial fistula is an exceedingly rare complication and has not been reported in the literature.

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“…Although high plasma concentrations of ANP and BNP have been found in patients with congenital heart disease and heart failure [1,23], the acute effects of ␤-adrenergic stimulation with dobutamine on the plasma ANP, BNP, …”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the ANP and BNP concentrations increase in parallel with an increase in the severity of heart failure, and increased ANP and BNP concentrations are associated with poor prognosis [16,17]. It also has been reported that the plasma concentrations of ANP and BNP are elevated in patients with congenital heart disease and heart failure [1,23].Although ANP and BNP concentrations at rest have been well characterized, there have been no studies on how the plasma concentrations of ANP, BNP, and cyclic guanosine monophosphate (cGMP), a second messenger for these peptides, change during ␤-adrenergic stimulation with dobutamine. In this study, we examined the effects of dobutamine on the plasma concentrations of ANP, BNP, and cGMP in patients with surgically repaired tetralogy of Fallot (TOF).…”

mentioning

confidence: 99%

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Plasma Concentrations of Atrial and Brain Natriuretic Peptides and Cyclic Guanosine Monophosphate in Response to Dobutamine Infusion in Patients with Surgically Repaired Tetralogy of Fallot

1999

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We examined the plasma concentrations of atrial and brain natriuretic peptides (ANP and BNP) and cyclic guanosine monophosphate (cGMP) during dobutamine infusion and their relationship with hemodynamic parameters in 14 patients with surgically repaired tetralogy of Fallot (TOF). Dobutamine was infused at an initial dose of 5 microgram/kg/min and increased by 5 microgram/kg/min up to 20 microgram/kg/min. The plasma ANP, BNP, and cGMP concentrations were determined before infusion, at the end of each stage, and 15 minutes after discontinuing dobutamine infusion. The plasma concentrations of ANP, BNP, and cGMP were elevated in all patients before dobutamine infusion. The ANP, BNP, and cGMP concentrations decreased in 11 of the 14 patients during dobutamine infusion. In contrast, the plasma ANP and BNP concentrations increased in the remaining 3 patients without a change in the cGMP concentration. The right ventricular pressure and volume were significantly elevated in these patients. The plasma cGMP concentration correlated with the ANP concentration (r = 0.62, p < 0.01) but not the BNP concentration. The plasma ANP concentration during dobutamine infusion correlated with right ventricular systolic pressure (r = 0.71, p < 0.05), mean right atrial pressure (r = 0.29, p < 0.05), and mean pulmonary capillary wedge pressure (r = 0.32, p < 0.05). The BNP concentration correlated with right ventricular volume (r = 0.61, p < 0.05) and systolic pressure (r = 0. 46, p < 0.05). In conclusion, rapid changes in ANP, BNP, and cGMP concentrations during dobutamine infusion reflect the changes in atrial and ventricle pressure and volume overload. In surgically repaired TOF, the ANP concentration is affected by right ventricular systolic pressure, right atrial pressure, and pulmonary capillary pressure. Furthermore, the BNP concentration reflects right ventricular pressure and volume overload.

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Studies of cardiopulmonary bypass in children: implications for the regulation of brain natriuretic peptide

Abstract: The major source of plasma BNP in patients with congenital heart disease is the cardiac ventricle. The lower plasma ANP and BNP levels and the narrow band of change in central venous pressure following surgical repair of cardiac abnormalities may be a response to improved cardiac function.

Cited by 45 publications

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Impact of cardiac surgery on plasma levels of B-type natriuretic peptide in children with congenital heart disease

Impact of cardiac surgery on plasma levels of B-type natriuretic peptide in children with congenital heart disease

Brain Natriuretic Peptide (BNP) in Patients Undergoing Coronary Artery Bypass Grafting

Plasma Concentrations of Atrial and Brain Natriuretic Peptides and Cyclic Guanosine Monophosphate in Response to Dobutamine Infusion in Patients with Surgically Repaired Tetralogy of Fallot

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