Studies of Factors Involved in the Production of Low Tension Glaucoma

Drance, Stephen M.; Sweeney, Vincent P.; Morgan, Robert W.; Feldman, Fred

doi:10.1001/archopht.1973.01000040459003

Cited by 286 publications

(134 citation statements)

References 16 publications

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“…3,[13][14][15][16] The aetiology of optic disc haemorrhage is still unclear, but many studies have shown that glaucoma is associated with haemorrhage. Rim notching, RNFL defects, and visual field deterioration are suspected to be associated with optic disc haemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Risk factors associated with optic disc haemorrhage in patients with normal tension glaucoma

et al. 2009

Eye

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Purpose To evaluate the risk factors associated with optic disc haemorrhage in patients with normal tension glaucoma (NTG). Patients and methods Two hundred and eighty-one eyes of 281 patients with NTG (113 eyes with optic disc haemorrhage and 168 eyes without haemorrhage) were included in this study. Associations between optic disc haemorrhage and various patient-related variables (diabetes; hypertension; hypotension; cardiac disease; stroke; cold hand; migraine; constipation; use of steroids, aspirin, anticoagulant, or gingko extract; smoking history; and glaucoma family history) and eye-related variables (baseline intraocular pressure (IOP); maximum, minimum, and range of IOP; vertical and horizontal cup/disc ratio; mean deviation and pattern standard deviation of the visual field; corneal thickness; and average retinal nerve fibre layer (RNFL) thickness measured by optical coherence tomography) were investigated by univariate and multivariate logistic regression analyses. Differences in risk factors between patients with single optic disc haemorrhages and recurrent haemorrhages were also analysed. Results Optic disc haemorrhage was associated with systemic hypertension (odds ratio, 1.998; 95% confidence interval, 1.094-3.651; P ¼ 0.001). IOP range (P ¼ 0.080), diabetes (P ¼ 0.056), and use of aspirin (P ¼ 0.079) also tended to be associated with optic disc haemorrhage. No risk factor was significantly different between the single haemorrhage group and the recurrent haemorrhage group. ConclusionOptic disc haemorrhage was associated with systemic hypertension in patients with NTG.

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Section: Discussionmentioning

confidence: 99%

Risk factors associated with optic disc haemorrhage in patients with normal tension glaucoma

et al. 2009

Eye

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“…After that, many studies are present in the literature indicating a relationship between glaucoma and migraine either as a cause or a factor for progression. 1,2,[19][20][21][22][23][24][25][26][27] Recently, visual field abnormalities of migraine patients in SWAP testing was further analysed by us and we found that 53.3% of migraine patients had abnormal glaucoma hemifield tests, which is highly specific to glaucoma disease. …”

Section: Discussionmentioning

confidence: 99%

Assessment of spatial–contrast function and short-wavelength sensitivity deficits in patients with migraine

Yenice

Onal

Incili

et al. 2006

Eye

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Aims To study spatial-contrast function and short-wavelength sensitivity deficits in a migraine population with a disease duration of 30 years or less. Materials and methods In this prospective, cross-sectional study, we evaluated 28 subjects with migraine headache and 15 nonheadache healthy controls. Visual fields were evaluated using the Humphrey Field Analyzer 750i and the 30-2, blue and yellow threshold programme. Contrast sensitivity (CS) was measured at 1.5, 3, 6, 12, and 18 cpd spatial frequencies, using the Functional Acuity Contrast Test (F.A.C.T.TM ).The results of the visual field parameters (mean defect (MD) and pattern standard defect (PSD)) and CS were compared with 15 age-equivalent normal subjects.Results Short-wavelength amplitude perimetry (SWAP) parameters and CS scores at all spatial frequencies were significantly altered in the migraine patients when compared with the control subjects. Visual field parameters correlated significantly with contrast sensitivity scores: positively for MD (r ¼ 0.39, P ¼ 0.01; r ¼ 0.43, P ¼ 0.005; r ¼ 0.56, P ¼ 0.0001; r ¼ 0.45, P ¼ 0.003; r ¼ 0.48, P ¼ 0.0001) and negatively for PSD (r ¼ À0.45, P ¼ 0.003; r ¼ À0.45, P ¼ 0.003; r ¼ À0.51, P ¼ 0.001; r ¼ À0.53, P ¼ 0.0001; and r ¼ À0.67, P ¼ 0.0001) at all (1.5, 3, 6,12, and 18 cpd) spatial frequencies, respectively. Migraine duration correlated negatively with MD (r ¼ À0.42, P ¼ 0.04) and positively with PSD (r ¼ 0.42, P ¼ 0.03). Conclusion Migraineurs had significantly altered visual field and contrast function at all spatial frequencies to the normal population.These defects share some features with early stages of glaucoma and may relate a possibility for a common vascular disease pathogenesis in these two conditions.

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“…Although previous reports have cited a high occurrence of functional peripheral vasospasm (up to about 65%), 20,23 only 16 LoGTS participants (8.4%) reported a history compatible with Raynaud's phenomenon.…”

Section: Vasospasmmentioning

confidence: 74%

“…Earlier reports on gender distribution of LPG have reported greater frequency in women, 18,19 greater frequency in men, 20 or an equal distribution between the sexes. 17 …”

Section: Sexmentioning

confidence: 78%