Studies of inner ear blood flow in animals and human beings

Abstract

This article reviews current studies on inner ear blood flow, discusses their relevance to the maintenance of normal homeostasis of the inner ear, reports for the first time clear changes in fundamental properties of cochlear blood flow in the chronic hydropic ear, and describes the potential of applying laser Doppler flowmetry technology to the measurement of inner ear blood flow in human beings. Studies of the guinea pig in which perfusion pressure is varied demonstrate a broad range of autoregulatory capabilities of the inner ear vasculature. Gain factors range from 0.76 and higher for recovery for less than 1 minute of modified perfusion pressure. This is significantly greater than reports obtained for brain autoregulation. In a series of four investigations of cochlear blood flow in the hydropic ear in guinea pigs, a decreased responsiveness to electrical stimulation and direct stimulation of the superior cervical ganglia was found, indicating a change in sympathetic control of cochlear tone. Reduced vasomotion was observed, and autoregulatory capabilities were reduced. In human investigations, changes in cochlear blood flow were demonstrated with direct electrical stimulation of the round window and warm water irrigation of the ear canal, but not with carbogen breathing. Increased cochlear blood flow was observed with increased systemic blood pressure, and a remarkable decrease in cochlear blood flow was observed with the application of 1:10,000 epinephrine to the round window. These observations indicate the potential for development of laser Doppler flowmetry technology in the diagnosis and treatment of inner ear vascular disorders, and the animal Investigations suggest that changes may occur in the chronic hydropic ear that compromise autoregulation and thus increase the sensitivity of the hydropic ear to other stress factors. Treatments can be found to modify such changes in vascular tone.

Betahistine Increases Vestibular Blood Flow

“…The guinea pig model was used because of its extensive use for study of inner ear function, including inner ear blood flow. 7,[15][16][17][18][19] The well-established technique of laser Doppler flowmetry provided continuous in vivo measures of VBF. The posterior semicircular canal ampulla was chosen as a measurement site of blood flow because of its accessibility and the previous observation that flow in this region is representative of peripheral end-organ flow.…”

“…[14][15][16] Since the adaptation of this technique to the cochlea by Miller et al, 17 it has been used extensively for studies of CBF. 18,19 The adaptation of this measurement technique with an accepted model of inner ear function allows continuous in vivo measurements of VBF. The purpose of the current experiments, therefore, was to assess the ability of systemically infused BH to affect VBF in the guinea pig by use of laser Doppler flowmetry.…”

Association Between Retinal Pathology and Hearing in Older Adults

“…Vascular pathologies could contribute to hearing loss through impaired cochlear blood supply 6 . Visualization of cochlear microcirculation using well‐established clinical imaging modalities is challenging due to insufficient spatial resolution or contrast 7‐10 . The retinal microvasculature, however, can be imaged noninvasively to measure changes in cerebral microvasculature, 11‐14 changes that we hypothesize could apply to the enshrouded cochlear microvasculature.…”

Prevalence of Heat Shock Protein in Patients with Meniere's Disease and Allergy

“…Since Prosper Meniere first described the symptom complex that bears his name, its etiology has been ascribed to many possible causes, including underlying cochlear vascular pathology, 1 , 2 abnormalities in endolymph production or absorption, 3 , 4 abnormal ion homeostasis, 5 , 6 and allergic, 7 autoimmune or inflammatory, 8–10 and viral 11 – 12 causes.…”