1984
DOI: 10.1007/bf01868770
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Studies of sodium channels in rabbit urinary bladder by noise analysis

Abstract: Sodium channels in rabbit urinary bladder were studied by noise analysis. There are two components of short-circuit current (Isc) and correspondingly two components of apical Na+ entry, one amiloride-sensitive (termed IA and the A channel, respectively) and one amiloride-insensitive (IL and the leak pathway, respectively). The leak pathway gives rise to l/f noise, while the A channel in the presence of amiloride gives rise to Lorentzian noise. A two-state model of the A channel accounts well for how the corner… Show more

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Cited by 50 publications
(29 citation statements)
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“…Although direct proof is lacking, the data suggest that autoregulatory activation of Na+ channels also occurs by recruitment from cytoplasmic stores. A similar mechanism has been suggested by Garty & Edelman (1983) and Lewis et al (1984) whereby, in urinary bladder, new Na+ channels could be recruited from intracellular stores in response to physiological signals. Foskett & W.EJ.NELSKANDYK.C-YCHOU Spring (1985) also suggested that during volume regulation in Necturus gall-bladder, microfilaments allow cytoplasmic vesicles with ion channels to fuse with the cell membrane.…”
Section: Discussionmentioning
confidence: 82%
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“…Although direct proof is lacking, the data suggest that autoregulatory activation of Na+ channels also occurs by recruitment from cytoplasmic stores. A similar mechanism has been suggested by Garty & Edelman (1983) and Lewis et al (1984) whereby, in urinary bladder, new Na+ channels could be recruited from intracellular stores in response to physiological signals. Foskett & W.EJ.NELSKANDYK.C-YCHOU Spring (1985) also suggested that during volume regulation in Necturus gall-bladder, microfilaments allow cytoplasmic vesicles with ion channels to fuse with the cell membrane.…”
Section: Discussionmentioning
confidence: 82%
“…Effects of increasing external Na+ up to 100 mm have been described in terms of channel saturation in rat cortical collecting tubule (Palmer & Frindt, 1988) and in A6 Na+ channels reconstituted in planar lipid bilayers (Olans, Sariban-Sohraby & Benos, 1984). On the other hand, experiments using current fluctuation analysis on frog skin and rabbit urinary bladder (Van Driessche & Lindemann, 1979;Lewis et al 1984) found no evidence for single-channel current saturation in response to changes in external Na+. These authors concluded that Na+ permeability was modified primarily by regulating the number of active channels.…”
Section: Discussionmentioning
confidence: 99%
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“…124. 125] and the influence of the membrane potential on these constants [209,210], From these results the affinity constant of amiloride for its bind ing site (K0n/K0ff) could be measured; the observed value, between 0.1 and 0.3 p.l/, was generally lower than the inhibition constant determined by macroscopic SCC inhibition determination [119,122,124]. It could also be shown that the amiloride affinity is related to the membrane potential, as if the charged amiloride molecule would bind to a site located in the transmembrane electric field (at 10-30% of the membrane width if the electrical field is assumed to be constant across the whole membrane) [154, 156, 179, 209.…”
Section: C' Amiloride-sodium Channel Interactionsmentioning
confidence: 99%