Studies of synthesis routes for biologically active 14α-hydroxylated steroids

Abstract

The conditions for preparing 14a-hydroxyandrostenedione -an intermediate in the synthesis of highly active gestagens -using the fungus Curvularia lunata CBE with an increased steroid substrate load of 5 g/liter in the presence of methylcyclodextrin were identified. The microbiological method of introducing 14a-hydroxy groups into the androstane structure has significant advantages over chemical approaches from the technical and ecological points of view and for obtaining a higher yield.