Studies of the mechanism by which phosphate infusion lowers serum calcium concentration.

Hebert, Lee A.; Lemann, Jacob; Petersen, Jana; Lennon, Edward J.

doi:10.1172/jci105493

Cited by 228 publications

(78 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Under physiological conditions, calcium serum concentrations subject to strong homeostatic control and changes, such as hypo-or hypercalcemia, can only be measured in short-term experiments (Table 5). Herbert et al (1966) reported that phosphate infusion, diets high in phosphorus and oral supplementation of phosphates decrease the serum levels of calcium. This is probably due to biochemical interactions between calcium and phosphate (Reiss et al, 1970).…”

Section: Discussionmentioning

confidence: 99%

High phosphorus intake only slightly affects serum minerals, urinary pyridinium crosslinks and renal function in young women

et al. 2001

View full text Add to dashboard Cite

Objective: Assessment of the physiological effects of a diet rich in phosphorus in young women. Design: Control period I Ð commercial basic diet containing 1700 mg P and 1500 mg Caaday for 4 weeks. Supplementation period Ð a 6 week high-phosphorus period of 3008 mg P and 1995 mg Caaday. Control period II Ð 4 weeks washout with basic diet as in period I. Setting: Institute of Nutritional Science, Friedrich Schiller University, Jena. Subjects: Ten healthy women, aged 20 ± 30 y. Interventions: Orange juice and tablets, containing supplements of Ca 5 (PO 4 ) 3 OH and NaH 2 PO 4 , totalling 1436 mg elemental phosphorus per day. Results: There was an increase of 10.7 AE 13.7 pgaml in serum PTH, a decrease of 0.6AE 0.6 ngaml in serum osteocalcin, an increase of 73.6 AE 136.6 nmolammol creatinine in urinary pyridinoline and of 19.3 AE 36.0 nmola mmol creatinine in urinary deoxypyridinoline, and a decrease of 2.6 AE 9.3 mgal in urinary microalbumin. All changes were insigni®cant. There were no changes in serum levels of Ca, PO 4 or Zn, in serum concentration of 1,25-(OH) 2 D 3 , and in urinary b-2-microglobulin excretion. Phosphorus supplementation caused intestinal distress, soft stools or mild diarrhoea. Conclusions: In spite of a high phosphorus supplementation no signi®cant changes in bone-related hormones, pyridinium crosslinks as markers of bone resorption and parameters of renal function in young women were found.

show abstract

Section: Discussionmentioning

confidence: 99%

High phosphorus intake only slightly affects serum minerals, urinary pyridinium crosslinks and renal function in young women

et al. 2001

View full text Add to dashboard Cite

show abstract

“…Extraskeletal calcifications were occasionally demonstrated on plain xrays and slit-lamp examination (79). Clinical investigations confirmed that phosphate administration lowered serum calcium primarily through Ca-Pi deposition (80,81).…”

Section: Hyperphosphaturia and Kidney Injurymentioning

confidence: 95%

Adverse Renal and Metabolic Effects Associated with Oral Sodium Phosphate Bowel Preparation

Heher¹,

Thier²,

Rennke³

et al. 2008

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Colorectal cancer can be prevented by the removal of adenomatous polyps during screening colonoscopy, but adequate bowel preparation is required. Oral sodium phosphate (OSP), an effective bowel purgative, is available over the counter and requires a substantially lower volume than polyethylene glycol-based preparative agents. Accumulating reports implicate OSP in electrolyte disturbances as well as acute kidney injury (AKI) in a syndrome termed phosphate nephropathy (a form of nephrocalcinosis). Despite published case reports and case series, the actual incidence, risk factors, and natural history of phosphate nephropathy remain largely undefined. Several recent observational studies have provided new information on these important issues while supporting a link between OSP and acute phosphate nephropathy as well as the development of chronic kidney disease in elderly patients, many of whom had a normal serum creatinine at the time of OSP ingestion. This review summarizes current knowledge about the renal complications of OSP, risk factors for its development, and the pathophysiology of acute and chronic kidney damage in nephrocalcinosis.

show abstract

“…Such a marked increase in urinary calcium excretion has been reported during phosphate depletion in humans (1,2), sheep (3), and rats (4). Conversely, the acute administration of phosphate causes a significant reduction in urinary calcium (5)(6)(7)(8)(9). The mechanism through which phosphate affects the renal handling of calcium have not been well delineated.…”

Section: Introductionmentioning

confidence: 99%

Changes in serum and urinary calcium during phosphate depletion: studies on mechanisms

Coburn¹,

Massry²

1970

J. Clin. Invest.

127

View full text Add to dashboard Cite

ABSTRA CT The changes in serum calcium and the renal handling of this ion were evaluated during phosphate depletion. 96 renal clearance studies were carried out in 10 dogs before and after prolonged phosphate depletion (30-160 days) and after repletion. Depletion was produced by reducing phosphate intake and administering aluminum hydroxide gel while intakes of sodium, calcium, and magnesium were constant. With phosphate depletion, serum phosphorus fell to less than 1.0 mg/100 ml and diffusible serum calcium either remained unchanged or rose transiently. Glomerular filtration rate (GFR) fell by 15 to 53%. Despite the reduced filtered load of calcium, its fractional excretion increased in most experiments. This hypercalciuria was not dependent upon changes in sodium or magnesium excretion, or the urinary concentration of complexing anions, and persisted after sodium restriction. Phosphate repletion reversed the effects on GFR and calcium excretion. The intravenous infusion of small quantities of phosphate (0.04 mmole/min) into either intact or thyroparathyroidectomized (T-PTX), phosphate-depleted animals caused a significant reduction in fractional excretion of calcium, but the intrarenal infusion of 0.02 mmole/min of phosphate into one kidney failed to produce an ipsilateral effect. The administration of parathyroid extract reduced fractional calcium excretion, but the latter remained significantly elevated. After T-PTX, fractional calcium excretion did not increase in the phosphate-depleted animals. Furthermore, serum calcium was normal after T-PTX until serum phosphorus increased slightly, and

show abstract

Studies of the mechanism by which phosphate infusion lowers serum calcium concentration.

Abstract: It has long been known that oral or intravenous administration of phosphate salts lowers the serum calcium concentration in normal animals (1, 2) and in hypercalcemic human subjects (3)(4)(5)

Cited by 228 publications

References 12 publications

High phosphorus intake only slightly affects serum minerals, urinary pyridinium crosslinks and renal function in young women

High phosphorus intake only slightly affects serum minerals, urinary pyridinium crosslinks and renal function in young women

Adverse Renal and Metabolic Effects Associated with Oral Sodium Phosphate Bowel Preparation

Changes in serum and urinary calcium during phosphate depletion: studies on mechanisms

Contact Info

Product

Resources

About