1980
DOI: 10.1016/s0171-2985(80)80009-x
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Studies of the Producer Cell of Herpes Simplex Virus-Induced Interferon in Mouse Spleen Cell Cultures

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Cited by 10 publications
(3 citation statements)
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“…This low frequency of murine IPCs resembles that of the Natural IFN-/ producing cells (NIPC) in human [16,18,19] and pigs [9,20]. With regard to the identity of the murine IPCs, inactivated HSV was reported to induce IFN-production in murine spleen cells that were not T cells, NK cells or macrophages [21]. Further characterization of their phenotype is necessary to establish whether such IPCs are the murine counterpart of the human and porcine NIPC.…”
Section: Discussionmentioning
confidence: 95%
“…This low frequency of murine IPCs resembles that of the Natural IFN-/ producing cells (NIPC) in human [16,18,19] and pigs [9,20]. With regard to the identity of the murine IPCs, inactivated HSV was reported to induce IFN-production in murine spleen cells that were not T cells, NK cells or macrophages [21]. Further characterization of their phenotype is necessary to establish whether such IPCs are the murine counterpart of the human and porcine NIPC.…”
Section: Discussionmentioning
confidence: 95%
“…Studies by Lopez (1978) have suggested that protection is a bone marrow-dependent function and preliminary data from our laboratory have suggested that interferon may play a role in protection (Zawatzky et al, 1979). Both conclusions may be linked together if interferon production turns out to be a property of bone marrow-dependent cells, which may indeed be the case (Kirchner et aL, 1980). In the present paper we report on humoral and cellular immunity and various parameters of non-specific defence mechanisms [e.g.…”
Section: Introductionmentioning
confidence: 81%
“…Again, we have found a correlation between high interferon production and in vivo resistance. Recent data have strongly suggested, although not unequivocally proved, that the producer cell of interferon was a B cell (Kirchner et al, 1980 . We intend to analyse the HSV-induced interferon production but we already know that interferon production, like resistance (Lopez, 1975), is independent of the H-2 complex as the comparison between BI0 and B10.D2 mice has shown.…”
Section: Discussionmentioning
confidence: 99%