Studies of the relationship between chemical structure and porphyria-inducing activity—IV

Schneck, Dennis W.; Racz, William J.; Hirsch, G. H.; Bubbar, G. L.; Marks, Gerald S.

doi:10.1016/0006-2952(68)90075-0

Cited by 18 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several drugs induce 5-ALA synthetase in chick embryo liver cells in culture [Granick, 1966;Schneck et al, 1968;Doss, 1969]. In this sys tem it is not possible to distinguish two different groups of drugs, as in rat liver: thiopentone and lindane are as good inducers as AIA and DDC and in general the effectiveness of a drug as an inducer reflects fairly closely its lipid-solublity with no requirement for a special chemical constitution [DeMatteis, 1971a].…”

Section: Discussionmentioning

confidence: 99%

Drug Interactions in Experimental Hepatic Porphyria

F¹

1973

Enzyme

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Drug Interactions in Experimental Hepatic Porphyria

F¹

1973

Enzyme

View full text Add to dashboard Cite

“…and 2-(2.4,6h-imethylphenyl) cthanamide (Schneck et al 1968); B1A (Marks et al 1973). The following compounds were purchased; 3,3',4.4'-tetrachlorobiphenyl and 2,2',4.4'.6,6'-hexachlorobiphenyl (Ultra Scient~flc, Hope, KI); ethyl benzoate and diethyl glutarate (Eastman Kodak Cu , Rochester, NY); I-adamarrtaraeethanol (Aidrich Chemical Co. Ltd., Milwaukee, WI); 5a-andrc~stan-3aol-17-one, Sp-androstan-3ac~1-17-one.…”

Section: Methodsmentioning

confidence: 99%

Patterns of porphyrin accumulation in response to chemicals in chick embryo liver cells

Marks¹,

Follows²,

Zelt³

et al. 1983

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

Four patterns of porphyrin accumulation were observed by high-pressure liquid chromatography when chemicals were added to chick embryo liver cells. These patterns provide a guide to the site of action of the chemicals. Protoporphyrin accumulated in response to 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC), a result consistent with its ability to inhibit ferrochelatase. Uroporphyrin and heptacarboxylic acid porphyrin accumulated in response to 3,3',4,4'-tetrachlorobiphenyl, 2,2',4,4',6,6'-hexachlorobiphenyl, and 3,5-diethoxycarbonyl-2,4,6-trimethylpyridine, a result suggesting inhibition of uroporphyrinogen decarboxylase. Coproporphyrin was the major porphyrin to accumulate in response to allylisopropylacetamide, aromatic amides, and steroids, a result suggesting inhibition of coproporphyrinogen oxidase. A mixture of uroporphyrin, heptacarboxylic acid porphyrin and coproporphyrin accumulated in response to aromatic di- and mono-esters, aliphatic diesters, and aliphatic amides. The pattern observed after addition of excess delta-aminolevulinic acid (ALA) the endogenous substrate of the pathway to the cells was proto- greater than copro- greater than uro-porphyrin. This pattern resembled that produced by DDC but by none of the other chemicals. It was concluded that porphyrin accumulation can not be attributed solely to the induction of ALA-synthetase. It appears that porphyrin-inducing chemicals exert an additional effect on one or other of the enzymes of the heme biosynthetic pathway.

show abstract

“…Additional analogs of griseofulvin (a reference in quotes indicates synthetic procedure): 137a (ref “”), 137b (ref “”), 138 (ref “”), 139 (refs “ ”, , , , “ ”), 140 (ref “”), 141a (ref “”), 141b (refs “ ”, , , “”, , “ ”), 142 (ref “”), 143 (ref “”), and 144 (refs “ ”, , ).…”

Section: Synthetic Griseofulvin Analogsmentioning

confidence: 99%