Studies of total and high density lipoprotein cholesterol in childhood malaria: a preliminary study

Agbedana, E O; Ls, Salimonu; Taylor, G. Oladunni; Williams, A. I. O.

doi:10.1080/00034983.1990.11812505

Cited by 5 publications

(10 citation statements)

References 8 publications

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“…In accordance, previous studies and a recent metaanalysis showed congruent lipid profile changes during malaria infection. [2][3][4][5]7,8,10,11,13,14,24,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] The meta-analysis (2013) was updated with the data of the present study, further strengthening the findings of that study. 7 The extent of these serum lipid profile changes was not related to parasitemia, in contrast to three other studies.…”

Section: Discussionmentioning

confidence: 65%

“…7 It has been suggested that these lipid changes were lower compared with other febrile illnesses and thus characteristic of malaria. 7 However, this was concluded from a meta-analysis that included only few studies: three for TC, [8][9][10] two for HDL-C, 8,10 one for LDL-C, 10 and two for triglycerides (TGs). 10,11 Although TG levels seem to increase in malaria patients compared with healthy individuals, a statistical difference with other febrile diseases could not be demonstrated.…”

Section: Introductionmentioning

confidence: 99%

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Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon

Visser

Vries

Vingerling

et al. 2017

The American Society of Tropical Medicine and Hygiene

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Abstract. The serum lipid profile in malaria patients has been found to differ from that of healthy controls. We investigated serum lipid profile changes in malaria patients over time compared with patients with other febrile diseases. In total, 217 patients were included in the study (111 malaria patients and 106 symptomatic controls, defined as malaria-negative febrile patients). Serum lipid levels (mmol/L) were significantly lower in malaria patients compared with those with other febrile diseases (total cholesterol . No significant differences were found for apolipoprotein A1, apolipoprotein B, and lipoprotein(a). Cholesterol levels increased toward reference values on day 28 ( TC = 3.26-3.98, P < 0.001; HDL-C = 0.43-0.96, P < 0.001; LDL-C = 2.05-2.60, P < 0.001). TG levels decreased from 1.81 on admission to 1.76 (day 3) and 0.88 (day 28; P = 0.130). Lipid profile changes were not correlated with parasitemia or Plasmodium falciparum histidine-rich protein 2 levels. This study confirms characteristic temporary lipid profile changes in malaria. Lipid profile changes demonstrated a good accuracy to discriminate between malaria and other febrile diseases (area under the curve = 0.80 (95% confidence interval = 0.742-0.863, P < 0.001). Several plausible hypotheses exist regarding the pathophysiology of lipid profile changes in malaria. Further studies to elucidate the precise pathways may lead to improved understanding of the underlying pathophysiology.[

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Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon

Visser

Vries

Vingerling

et al. 2017

The American Society of Tropical Medicine and Hygiene

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“…Forty-two records [1,5-16,30-57] met the inclusion criteria (Additional file 7: Table S1). Of these, n = 15 for cholesterol [7,9,10,12,30,31,33,35],[38,40,42,44,46,50,52,54]; nine for HDL [10,12,30,33,35,38,42,44],[52]; eight for LDL [10,12,30,33,35,38,42,52]; nine for triglycerides [10,12,30,33,35,40,42,50],[52], contained the necessary data for inclusion in the quantitative analysis (meta-analysis); see PRISMA flow diagram (Figure 1). Four records [11,13,14,47] were excluded from the quantitative synthesis either because means and SD were not reported (n = 3), or mean differences and SD could not be calculated from the available data (n = 1).…”

Section: Resultsmentioning

confidence: 99%

“…In total, 3,442 patients with malaria were analysed in these studies, and compared with 1,686 controls (patients negative for malaria). Thirty-five were adult studies and seven were paediatric studies [14,30,31,36,44,52,55]. In 26 of these 42 records, serum lipid profiles of malaria patients were compared to a control group.…”

Section: Resultsmentioning

confidence: 99%

“…In 26 of these 42 records, serum lipid profiles of malaria patients were compared to a control group. These control groups consisted of healthy controls (15 studies) [7,9,11,12,14,30,31,33],[38,40,44,47,50] or “symptomatic” controls [16,35,37,44,46] (malaria-like symptoms but negative for malaria). There were two records including controls with a (very) low parasitaemia [10,32]; one of these two [32] did not report the necessary data and was therefore excluded from the meta-analysis; the other study [10] was included in the meta-analysis for healthy controls.…”

Section: Resultsmentioning

confidence: 99%

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Serum lipids and lipoproteins in malaria - a systematic review and meta-analysis

Visser

Wieten

Nagel

et al. 2013

Malar J

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BackgroundSerum lipid profile changes have been observed during malaria infection. The underlying biological mechanisms remain unclear. The aim of this paper is to provide an overview on those serum lipid profile changes, and to discuss possible underlying biological mechanisms and the role of lipids in malaria pathogenesis.MethodsA systematic review and meta-analysis to determine lipid profile changes during malaria was conducted, following PRISMA guidelines. Without language restrictions, Medline/PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, LILACS, Biosis Previews and the African Index Medicus were searched for studies published up to 11 July, 2013, that measured serum lipid parameters in malaria patients. Also, major trial registries were searched. Mean differences in lipid profile parameters were combined in fixed and random effects meta-analysis, with a separate analysis for different groups of controls (healthy, other febrile illnesses or very low parasitaemia). These parameters were also compared between severe malaria and uncomplicated malaria. Funnel plots were used to test for publication bias.ResultsOf 2,518 studies reviewed, 42 met the criteria for inclusion in the qualitative analysis, and of these, 15 reported the necessary data for inclusion in the meta-analysis for cholesterol; nine for high-density lipoprotein (HDL), eight for low-density lipoprotein (LDL), and nine for triglycerides, respectively. Total cholesterol, HDL and LDL concentrations were lower in malaria and other febrile diseases compared to healthy controls. The decline was more pronounced and statistically significant during malaria compared to other febrile diseases. These results were consistent across included studies. Triglycerides were raised compared to healthy controls, but not statistically significant when compared to symptomatic controls.ConclusionsThis meta-analysis suggests that the observed lipid profile changes are characteristic for malaria. Although a definite link with the pathogenesis of malaria cannot yet be demonstrated, plausible hypotheses of biological mechanisms involving host lipid alterations and the pathogenesis of malaria exist. An increased research effort to elucidate the precise pathways is warranted, since this could lead to better understanding of malaria pathophysiology and consequently to novel treatment approaches.

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Platelet-activating factor and lipid metabolism in acute malaria

Davis

Sturm

Zhang³

et al. 1993

Journal of Infection

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Studies of total and high density lipoprotein cholesterol in childhood malaria: a preliminary study

Cited by 5 publications

References 8 publications

Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon

Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon

Serum lipids and lipoproteins in malaria - a systematic review and meta-analysis

Platelet-activating factor and lipid metabolism in acute malaria

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