Studies of zinc phthalocyanine/magnetic fluid complex as a bifunctional agent for cancer treatment

Oliveira, Dutra de; Macaroff, P.P.; Ribeiro, Karina F.; Lacava, Z.G.M.; Azevedo, Ricardo Bentes; Lima, E.C.D.; Morais, P.C.; Tedesco, Antônio Cláudio

doi:10.1016/j.jmmm.2004.11.134

Cited by 28 publications

(14 citation statements)

References 11 publications

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“…HPT is, very simply, the application of concentrated therapeutic heat to treat cancer [12]. HPT increases the cellular uptake of oxygen because the heating up of the cell causes dilation, which allows free flow of oxygenated blood to the cells.…”

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confidence: 99%

The use of phthalocyanines in cancer therapy

Nyokong¹,

Gledhill²

2013

AIP Conference Proceedings

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Abstract. Phthalocyanines are synthetic analogues of porphyrins employed as photosensitizers in cancer therapy. We present the history of photodynamic therapy and developments in the use of phthalocyanines as photosensitizers. New efforts in the development of more cancer-specific phthalocyanines are presented. The combination of phthalocyanines with nanoparticles for "combination therapy" of cancer is also discussed. The nanoparticles employed are quantum dots, gold, and magnetic nanoparticles.

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confidence: 99%

The use of phthalocyanines in cancer therapy

Nyokong¹,

Gledhill²

2013

AIP Conference Proceedings

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“…In addition to encapsulation of nanosized particles into biocompatible hosting templates therapeutic molecules can be included for further delivery as well, either within the template [99][100][101][102][103][104][105][106][107][108] or decorating the outer surface of the template or, alternatively, decorating the encapsulated nanoparticles [109][110][111][112][113][114]. Indeed, vectorization of these material systems to target specific cells and tissues can be realized extrinsically using gradients of magnetic fields [10] or intrinsically by dressing the materials' surface with cell receptor-responsive moieties [84,115].…”

Section: Thermoresponsive Drug Delivery Systemsmentioning

confidence: 99%

Remote Hyperthermia, Drug Delivery and Thermometry: The Multifunctional Platform Provided by Nanoparticles

Qi¹,

Morais

2014

J Nanomed Nanotechno

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The huge demand for biocompatible, robust, accurate and noninvasive technology to assess the temperature of a biological targeted site for monitoring the hyperthermia effect brings the topic of remote thermometry to a very high level of interest. There are already promising research directions to fulfil such demand in the short term and a review of the achievements in this issue is certainly worth. This report offers an overview of the research regarding the most promising nanothermometers nowadays, with emphasis on those addressed to remote operation while using optical or magnetic responses of nanosized materials as the thermometric property. More specifically the optical emission intensity, optical emission peak shift and optical emission lifetime will be covered as far as the optical-based nanothermometers are concerned. Additionally, for the magnetic-based nanothermometers the magnetization or the magnetic susceptibility are the thermometric properties covered in this review. Furthermore, the review includes the hyperthermia effect based on nanosized metallic or magnetic particles plus a couple of thermally-responsive polymeric drug delivery systems, aiming to provide an integrated view of the multipurpose platform offered by actuating-sensing nanoparticles. As far as the regulatory system is concerned the availability of noninvasive thermometry incorporating biocompatibility, robustness and accuracy will establish the grounds needed for the approval of the hyperthermia technology for therapeutic purposes, thus allowing the market of this technological option on a global scale.hyperthermia and thermoresponsive drug delivery systems for clinical use.Although nanothermometry is at its infancy considerable progress has been made recently in regard to its use for remote assessing the temperature at the site the nanomaterials are incorporated to. Nanoprobes allowing remote temperature-sensing using optical or magnetic properties are among the most promising directions nowadays. Most of the optical-based nanothermometers use the light-emitting intensity [15][16][17][18][19][20][21][22][23], light-emitting peak shift [24][25][26], or lifetime decay of a suitable optical band as the thermometric property [27][28][29][30]. As far as the clinical use is concerned the drawbacks of the actual optical-based nanothermometers rely on biocompatibility (usual semiconductor-based core nanoprobes or dye-based shell moieties are toxic), robustness (typical bleaching of organic-based shell moieties) or temperature accuracy (no better than 0.3°C nowadays), or even combination of these factors. Moreover, due to limitations imposed by living tissues on the optical penetration of light (optical therapeutic window in the 700-1100 nm wavelength range), noninvasive clinical use of optical excitation and signal pickup is a huge challenge, not yet solved, except for very special therapeutic applications, as for instance the photodynamic therapy for treatment (heating monitoring) of skin cancer and follow up [31]. Alternatively, ...

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“…39 This phenomenon is in good agreement with reported results. 40,41 Solubility The substitution of Pcs decreases intermolecular interactions, which prohibits them forming dimers. Thus, substituents on the periphery of a Pc significantly enhances its solubility in organic solvents, such as in pyridine, chloroform, acetone and DMF.…”

Section: Fluorescent Characterisationmentioning

confidence: 99%

Synthesis and Spectroscopic Properties of a Series of Metal-Free and Metallo-Phthalocyanines Substituted with 8-Quinolinoxy Moieties

et al. 2011

Journal of Chemical Research

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Peripherally tetraquinolinoxy-substituted, metal-free phthalocyanines and metallo-phthalocyanines 1c-f, 2c-f have been synthesised by reaction of an inorganic salt with phthalonitriles substituted with 5-(phenylamino)methyl-8-quinolinoxy and 5-[(4-chlorophenylamino)methyl]-8-quinolinoxy groups, respectively. The effects of metal ions [Zn(II), Cu(II), Co(II); N,i(II)], substituent, solvent and concentration on the UV-Vis spectra of these new complexes and their fluorescent properties are also described. The diamagnetic Zn(II) and Ni(II) complexes display intense fluorescence.

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Studies of zinc phthalocyanine/magnetic fluid complex as a bifunctional agent for cancer treatment

Cited by 28 publications

References 11 publications

The use of phthalocyanines in cancer therapy

The use of phthalocyanines in cancer therapy

Remote Hyperthermia, Drug Delivery and Thermometry: The Multifunctional Platform Provided by Nanoparticles

Synthesis and Spectroscopic Properties of a Series of Metal-Free and Metallo-Phthalocyanines Substituted with 8-Quinolinoxy Moieties

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