Studies on alkaloids from Thalictrum species

Mollov, N. M.; Dutschewska, H.

doi:10.1016/0040-4039(64)83163-4

Cited by 5 publications

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“…From the aerial parts as well as the roots a great number of alkaloids with different structures have been isolated; most of these alkaloids contain the isoquinoline nucleus (1)(2).…”

Section: Introductionmentioning

confidence: 99%

Isolation of Quaternary Alkaloids fromThalictrum minusvar.minus.

Aynehchi

1979

Quarterly Journal of Crude Drug Research

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“…From the aerial parts as well as the roots a great number of alkaloids with different structures have been isolated; most of these alkaloids contain the isoquinoline nucleus (1)(2).…”

Section: Introductionmentioning

confidence: 99%

Isolation of Quaternary Alkaloids fromThalictrum minusvar.minus.

Aynehchi

1979

Quarterly Journal of Crude Drug Research

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“…Two ether bridges-8-7'; 11-12': (92) hemandezine (thalicsimine), (93) thalidezine, (94) isothalidezine, (95) JV-desmethylthalidezine, (96) obamegine, (97) thalrugosine, (98) berbamine, (99) isotetrandrine (O-methylberbamine), (100) thalsimine, (101) JV-norhemandezine, (102) thalibrunine, (103) JV-northalibrunine, (104) thalibrunimine, (105) oxothalibnmimine, (106) thalictrinine, (107) dihydrothalictrinine, (108) thalisamine, (109) thalsimidine. IV.…”

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confidence: 99%

Chemosystematics of Thalictrum minus Complex

Dutschewska¹,

Kuzmanov²

1982

J. Nat. Prod.

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Twenty-eight native Bulgarian populations of Thalictrum minus complex (Ranunculaceae) show a clear correlation between the cytotype and the type of dimer isoquinoline alkaloids (2n=42 with BBI and 2n=70 with ABI alkaloids). A similar correlation is evident also in the genus Thalictrum L. There are probably different evolutionary lines: in one the biogenesis reaches to the BBI types and in the other to the ABI types.

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“…Racemic 2b was previously obtained by catalytic reduction of 6a,7-dehydrohernandaline, 16 but it was not fully characterized. It has been reported that racemization occurs when alkaloids are reduced under the conditions used in the Pt02 reduction of hernandaline to synthetic hernandalinol (2b),15 and this most likely accounts for the lowered optical rotation of synthetic 2b.…”

Section: Resultsmentioning

confidence: 99%

Microbial transformations of natural antitumor agents. 3. Conversion of thalicarpine to (+)-hernandalinol by Streptomyces punipalus

Nabih

Davis²,

Caputo

et al. 1977

J. Med. Chem.

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Microbial transformation studies were conducted with the antitumor alkaloid thalicarpine. Streptomyces punipalus (NRRL 3529) converted thalicarpine to (+)-hernandalinol, the structure of which was determined spectroscopically and by synthesis from the known alkaloid hernandaline. This unusual biotransformation reaction most likely occurs by oxidative cleavage of the isoquinoline ring from thalicarpine through the intermediate hernandaline, which then undergoes further reduction to hernandalinol.

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Studies on alkaloids from Thalictrum species

Cited by 5 publications

References 0 publications

Isolation of Quaternary Alkaloids fromThalictrum minusvar.minus.

Isolation of Quaternary Alkaloids fromThalictrum minusvar.minus.

Chemosystematics of Thalictrum minus Complex

Microbial transformations of natural antitumor agents. 3. Conversion of thalicarpine to (+)-hernandalinol by Streptomyces punipalus

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