Studies on anti-complementary activity of extracts and isolated flavones from Ligustrum vulgare and Phillyrea latifolia leaves (Oleaceae)

Pieroni, Andréa; Pachaly, P.; Huang, Ying; Poel, B. Van; Vlietinck, A. J.

doi:10.1016/s0378-8741(99)00169-5

Cited by 47 publications

(43 citation statements)

References 8 publications

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“…These data agreed with the anti-complement properties of apigenin and its glycosides (apigenin 7-O-glucoside, apigenin 7-O-rutinoside), and luteolin and its glycosides (luteolin 7-O-glucoside, luteolin 4Ј-Oglycoside) isolated from Ligustrum vulgare and Phillyrea latifolia. 16) Of the compounds tested, 1,2,3,6-tetragalloylglucose (6) was found to be the most active compound with an IC 50 of 34 mM in this assay system. Comparing the galloylglucoses (5, 6) with flavonoids (1)(2)(3)(4) shown that the galloyl group might increase anti-complement properties.…”

Section: Anti-complement Activity Of Constituents From the Stem-bark mentioning

confidence: 84%

Anti-complement Activity of Constituents from the Stem-Bark of Juglans mandshurica

Min

Lee

Kim

et al. 2003

Biological & Pharmaceutical Bulletin

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Section: Anti-complement Activity Of Constituents From the Stem-bark mentioning

confidence: 84%

Anti-complement Activity of Constituents from the Stem-Bark of Juglans mandshurica

Min

Lee

Kim

et al. 2003

Biological & Pharmaceutical Bulletin

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“…The signals of proton and carbon of 9 were exacted by 1 Tables 1 and 2). By comparison of 13 C-NMR signals of 10 with those of 3, the chemical shift assignable to C-3Љ and 4Љ of 3 shifted downfield 2.9 and 3.0 ppm, respectively. The two methoxy group should be located at the C-3Љ and 4Љ position of the phenylethyl moiety in 10.…”

mentioning

confidence: 99%

Antioxidative Glucosides from the Fruits of Ligustrum lucidum.

But

Chan

et al. 2001

Chem. Pharm. Bull.

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The metabolic processes in the human body, inevitably, often produce harmful free radicals. These free radicals have been shown to possibly contribute to aging and various diseases, such as atherosclerosis and cancer.1-2) Therefore, it is important to identify effective radical scavengers to help relieve the damaging effects of free radicals. Our screening program for potent antioxidants from natural products have confirmed that polyphenolic compounds present in foods of plant origin do have strong radical scavenging and oxidationinhibiting effects. For example, the phenylethanoid glycosides from Brandisia hancei were found to have potent antioxidative properties. 3)Recently, our attention focused on the fruit of Ligustrum lucidum AIT. (Oleaceae), which is known as "Nuzhenzi" in China. It is commonly used in Chinese medicine to supplement "kidneys", nourish "yin", strengthen liver and clear vision.4) Previous studies reported that the fruit of L. lucidum has immunomodulatory, 5) hypolipemic, 6) antiinflammatory, 7) hepatoprotective, 8) antitumor 9) and antiaging effects. 10) Related species of the same genus showed inhibitory effect on acyl CoA cholesteryl acyltransferase, 11) and immunomodulatory 12) and anticomplementary activities. 13) These biological effects appear to support some of the ethnomedical claims. Chemical studies have found volatile components, triterpenes, flavonoids, secoiridoid glucosides, and phenolic compounds from this plant, and constituents such as phenylethanoids, monoterpenes, and secoiridoid glucosides from other Ligustrum species. 11,[14][15][16][17][18][19] In our screening program, ethanol extract of the fruits of L. lucidum showed antioxidative effect. Through bioassayguided analysis, ten secoiridoid glucosides were isolated from the active fractions. Two of the secoiridoid glucosides, lucidumosides C (9) and D (10), were new. Here we report the antioxidative activity of these constituents of Nuzhenzi against hemolysis of red blood cells (RBC) induced by free radicals, and also the structure elucidation of compounds 9 and 10.The fruits of L. lucidum were extracted with ethanol and the ethanol extract showed significant inhibitory effects (IC 50 ϭ125 mg/ml) on the hemolysis of RBC induced by free radicals (Fig. 1). The ethanol extract was partitioned with water into an aqueous fraction (A) and an insoluble fraction (B). The bioactivity of the ethanol extract against hemolysis of RBC test system was found concentrated in fraction A (IC 50 ϭ40 mg/ml). This fraction A was chromatographed on a porous polymer gel D-101 column with water, 60% aqueous ethanol and ethanol, to give fractions A1, A2 and A3 (Fig. 2). The biological activity was found concentrated in fraction A2, IC 50 being 31 mg/ml. From the active fraction A2, two new secoiridoid glucosides, lucidumosides C (9) and D (10), were isolated together with eight known secoiridoid glucosides, oleoside dimethyl ester (1), ligustroside (2), oleuropein (3), nuezhenide (4), isonuezhenid (5), neonuezhenide (6), lucidumoside A (7) and ...

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“…[4]. Phenylethanoid glycosides possess variable antioxidant properties, such as verbascoside which is reported to exhibit antimicrobial, anti-inflammatory, immunosuppressive, antitumour, diuretic and antibacterial activities [26]. Moreover, both these structural isomers are known to exhibit analgesic properties [27].…”

Section: Introductionmentioning

confidence: 99%

Separation and analysis of phenylethanoid glycosides inLamiophlomis rotataby high-performance liquid chromatography

et al. 2013

Acta Chromatographica

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Summary.A simple hydrolysis method has been developed for determination of phenylethanoid glycosides in Lamiophlomis rotata (L.R.). Different kinds of phenylethanoid glycosides were hydrolyzed in hydrochloric acid solution to produce corresponding phenethyl alcohols and cinnamic acids, mainly containing hydroxytyrosol, homovanillyl alcohol, 3,4-dimethoxyphenethyl alcohol, caffeic acid, fumalic acid and 3,4-dimethoxycinnamic acid. The six analytes could be determined simultaneously by high-performance liquid chromatography (HPLC). The effects of mobile phase, pH and concentration of running buffer, detection wavelength, flow rate and injection volume were also investigated. Under the optimum conditions, the six hydrolyzates could be perfectly separated within 45 min. The response was linear over four orders of magnitude with detection limits (S/N ＝ 3) ranging from 1 × 10 −8 to 1.5 × 10 −4 mol L −1 for the analytes. The method has been successfully applied to the analysis of real sample Du-Yi-Wei capsule and Qi-Zheng-Yan-Tong patch, with satisfactory results.

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Studies on anti-complementary activity of extracts and isolated flavones from Ligustrum vulgare and Phillyrea latifolia leaves (Oleaceae)

Cited by 47 publications

References 8 publications

Anti-complement Activity of Constituents from the Stem-Bark of Juglans mandshurica

Anti-complement Activity of Constituents from the Stem-Bark of Juglans mandshurica

Antioxidative Glucosides from the Fruits of Ligustrum lucidum.

Separation and analysis of phenylethanoid glycosides inLamiophlomis rotataby high-performance liquid chromatography

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