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N-Formylannonaine ( 1), N-formylnornuciferine ( 2) and N-acetylnornuciferin ( 3), have been isolated from stems of TINOSPORA CRISPA (Menispermaceae), and their NMR-spectra have been fully assigned by 2D-NMR experiments. This is the first reported occurrence of N-formyl- and N-acetylaporphines from the genus TINOSPORA.

In order to evaluate the pharmacological activities of Chinese medicine, nine Umbelliferae plants were selected and their restoring activity against dexamethasone-induced disorders, liver protective activity, antimicrobial activity, anti-inflammatory activity and antimutagenic activity were tested and compared. Angelica dahurica. Angelica acutiloba and Ostericum koreanum showed various activities in these tests at the dose used in this study.

n-octacosanol is an normolipidemic aliphatic primary alcohol obtained from the plant Tinospora cordifolia Miers. In the present study, the plant stems were collected from five accessions namely Anniyalam, Chennai, Hassan, Vishakhapatnam and Bangalore between June and August. Later a simple HPTLC method has been established for determination of n-octacosanol in methanolic extracts of all these geographical sources using Toluene: Ethyl acetate: Formic acid (4.5:4.5:1 v/v) as mobile phase. Detection and quantification were performed by densitometric scanning at λ = 555 nm. The results of HPTLC estimation showed variation in n-octacosanol content in all the accessions. The extract from Anniyalam accession showed significantly higher amount of n-octacosanol (6.54%) and that of Vishakhapatnam showed the least (2.28%). Thus, the present work is helpful in selecting genotype of Tinospora cordifolia yielding highest percentage of n-octacosanol.

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