Studies on antidiarrhoeal activity of Punica granatum seed extract in rats

The Therapeutic Potential of Pomegranate and Its Products for Prevention of Cancer

“…Pomegranate fruit extracts/constituents possesses immense biological activities such as anticarcinogenic (Whitley et al, 2003;Afaq et al, 2005), antibacterial (Akiyama et al, 2001;Prashanth et al, 2001;Duman et al, 2009), antidiarrhoeal (Das et al, 1999), antifungal (Dutta et al, 1998), antiulcer (Gharzouli et al, 1999), antioxidant activity and free radical scavenging capability (Schubert et al, 1999;Aviram et al, 2000;Festa et al, 2001), strengthening of the immune system , prevention of heart disease (Johanningsmeier & Harris, 2011) and liver fibrosis (Thresiamma & Kuttan, 1996), and inhibition of lipid peroxidation even at lower concentrations than vitamin E . All these therapeutical activities are related to the presence of diverse 'phenolic compounds', including gallic acid, protocatechinunic acid, chlorogenic acid, caffeic acid, ferulic acid, coumaric acid, and catechin and hydrolysable tannins (such as punicalin, pedunculagin, punicalagin, corilagin, casuarinin, punicacortein, granatin and ellagic acid), and anthocyanins (delphinidin, cyanidin and pelargonidin 3-glucosides and 3,5-diglucosides) (Amakura et al, 2000;Noda et al, 2002;Poyrazoglu et al, 2002;Kulkarni & Aradya, 2005;Viuda-Martos et al, 2010).…”

Antimicrobial Ellagitannin of Punica granatum Fruits

“…(Punicaceae) is a shrub or small tree native to Asia 1 where its several parts have been used as an astringent, haemostatic, as a remedy for diabetes, as an anthelmintic specifically against tapeworms and for diarrhoea and dysentery. 2 In Brazil the fruits are known as "romã" and are used for the treatment of throat infections, coughs and fever. There are several commercial phytopreparations in Brazil containing extracts from pomegranate.…”

Pharmacology of Traditional Herbal Medicines and Their Active Principles Used in the Treatment of Peptic Ulcer, Diarrhoea and Inflammatory Bowel Disease

“…Methanol extract of seeds of P. granatum dose dependently reduced castor oil induced diarrhea. It also significantly inhibited gastrointestinal motility and PGE 2 mediated enteropooling in rats (Das et al, 1999). …”