Studies on antimicrobial effects of four ligands and their transition metal complexes with 8-mercaptoquinoline and pyridine terminal groups

Zhang, Lijie; Zhang, Jing-An; Zou, Xun-Zhong; Liu, Yajie; Li, Ning; Zhang, Zi-Jie; Liu, Yu

doi:10.1016/j.bmcl.2015.02.056

Cited by 10 publications

(1 citation statement)

References 21 publications

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“…They can be found in important antibiotic drugs including Streptomycin, Trimethoprim, Chlorhexidine, Polyhexamethylene bi-guanidine, etc. [14][15][16][17] Pyridine ring unit is known as a common structural feature employed in numerous pharmaceutically significant molecules 18 . It has been demonstrated by a large number of literature reports that there can be many medicinal applications of guanidine-pyridine hybrid compounds 19,20 .…”

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2019

IJPSR

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Guanidines were prepared by the condensation reaction of primary amine (-NH 2 ) with urea derivatives (R 2 NCONR 2 ) in the presence of POCl 3 . In this research guanidine-pyridine, hybrid derivatives were synthesized by substituted urea derivatives namely 1,1,3,3-tetramethylurea and N, N′-dimethylurea with 2-aminopyridine. The metal complexes were obtained by reaction of metal(II) chloride with guanidine ligands in the molar ratio 1:1 and 1:2 (M:L). The structure of synthesized compounds was assessed by nuclear magnetic resonance ( 1 H-NMR), Fourier-transform infrared spectroscopy (FT-IR), ultraviolet-visible (UV-Visible) mass spectroscopy studies and molar conductance. The measured molar conductance values indicated that the complexes were non-electrolytic. An octahedral geometry is proposed for the cobalt complexes but, square-planar geometry is suggested for both copper and nickel complexes. The synthesized compounds were also subjected to antibacterial study. Evaluation of antibacterial activities indicated that the metal complexes more inhibited the Gram-positive and Gram-negative bacteria strains as compared to the parent ligands. Among all the metal complexes the CuL 2 ′ showed highest antibacterial activity with zone inhibition diameter of 29 mm and MIC value of 15.62 µg/ml based on broth dilution method and 31.25 µg/ml based on agar dilution method.

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2019

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One Pot Synthesis and Biological Evaluation of Some New Pyridine‐3,5‐dicarbonitrile Derivatives

et al. 2018

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We have developed eco-friendly route for the synthesis of title compounds by using simple compounds like aromatic aldehydes, malononitrile, 4-bromothiophenol and NaHCO 3 . In continuation to this, a series of pyridine-3,5-dicarbonitriles were synthesized with excellent yields and assessed for their in vitro antitubercular and antimicrobial activity. The results of the antimicrobial study showed potent antimicrobial activity as compared to the standard drugs (Chloramphenicol and Griseofulvin). It was noticed that the presence of electron donating groups significantly increases the antibacterial activity of the newly synthesized compounds. The title compounds further evaluated for antitubercular activity and from the promising results, they were found to possess significant biological activity against M. tuberculosis.

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Biological evaluation of 2-(3,4-dihydroxyphenyl)-4-((4-methoxyphenyl)imino)-4H-chromene-3,5,7-triol: Design, synthesis, and molecular docking studies

Rajesh R,

Sangeetha

2025

Biocatalysis and Agricultural Biotechnology

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Studies on antimicrobial effects of four ligands and their transition metal complexes with 8-mercaptoquinoline and pyridine terminal groups

Cited by 10 publications

References 21 publications

Untitled

Untitled

One Pot Synthesis and Biological Evaluation of Some New Pyridine‐3,5‐dicarbonitrile Derivatives

Biological evaluation of 2-(3,4-dihydroxyphenyl)-4-((4-methoxyphenyl)imino)-4H-chromene-3,5,7-triol: Design, synthesis, and molecular docking studies

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