Studies on antimutagenic effects of guava (Psidium guajava) in Salmonella typhimurium

Grover, I. S.; Bala, Saroj

doi:10.1016/0165-1218(93)90133-x

Cited by 59 publications

(32 citation statements)

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“…The fruits are edible and are rich source of vitamin C and minerals. The leaf extract has a broad spectrum of activities against cough, bacterial infections, heamostasis (Jairaj et al 1999(Jairaj et al , 2000, diarrheas and narcotic properties (Lozoya et al 1990), antidiabetic (Obatomi et al 1994), antioxidant (Qian and Nihorimbere 2004), antimutagenic (Grover and Bala 1993;Matsuo et al 1994), abdominal pain, convulsions, epilepsy, cholera, insomnia and hypnotic effects (Lutterodt and Maleque, 1988;Meckes et al 1996). Our effort was to evaluate its leaf and unripe fruits for antimalarial activity.…”

Section: Discussionmentioning

confidence: 99%

Antiplasmodial activity of certain medicinal plants against chloroquine resistant Plasmodium berghei infected white albino BALB/c mice

et al. 2013

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In the present study of antimalarial efficacy, aqueous extracts of leaves and unripe fruits of Psidium guajava, leaves of Ocimum sanctum and leaves of Murraya koenigii are evaluated against Plasmodium berghei (chloroquine resistant NK65 strain) infected white albino BALB/c mice. A 7 days oral administration was adopted with different dosage viz., 350 mg, 750 mg and 1,000 mg/kg body weight as treatment schedule along with parasite (Group I) and drug control with Chloroquine, 50 mg/kg body weight (Group II). All the parts were extracted based on the decoction method, which is commonly seen among the villagers/tribes as their usual method of preparation of decoction for most of the ailments. The antimalarial activities were evaluated from the giemsa stained blood smears collected from different treated groups of mice used in this experiment. The antiplasmodial effect that is percent parasitaemia and percent suppression (values in parenthesis) showed by the treated groups of mice at 350 mg/kg b. wt. by the aqueous extracts of P. guajava leaves (Group III) was 19.8 ± 1.22 (73.7 %), P. guajava unripe fruits (Group IV) was 52.7 ± 2.19 (30.0 %), leaves of O. sanctum (Group V) was 64.0 ± 0.73 (15.1 %) and leaves of M. koenigii (Group VI) was 28.9 ± 0.81 (61.6 %) whereas at 750 mg/ kg b. wt., it all showed 10.3 ± 0.7 (80.2 %), 26.3 ± 0.52 (65.1 %), 42.0 ± 0.47 (44.2 %) and 14.9 ± 0.46 (71.5 %) whereas at 1,000 mg/kg b. wt. dose, it all showed 9.2 ± 0.39 (85.8 %), 25.6 ± 0.40 (62.0 %), 41.8 ± 0.29 (35.5 %) and 14.0 ± 0.42 (76.9 %) respectively. Keywords Medicinal plants ÁIn vivo antimalarial bioassay Á Mice Á P. berghei

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Section: Discussionmentioning

confidence: 99%

Antiplasmodial activity of certain medicinal plants against chloroquine resistant Plasmodium berghei infected white albino BALB/c mice

et al. 2013

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“…Many other effects of extracts of Psidium leaves have been reported, such as antinociceptive (5,6), CNS depressor (7), antimutagenic (8,9), antihyperglycemic (10) -but such effect was controversial (11) -, antidiarrheic (12), antibiotic (12,13), antiamebic and antispasmodic (14) effects, anticough (15), and narcotic-like activity (16).…”

Section: Introductionmentioning

confidence: 99%

Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium

Garcia

Nascimento

Santos

2003

Braz J Med Biol Res

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Many pharmacological effects have been ascribed to extracts of Psidium guajava L. (guava) leaves. However, in spite of its widespread use in Brazilian folk medicine and a reasonable number of scientific reports about it, we could not find any study dealing with its action on the mammalian myocardium. In the present study, by measuring isometric force, we observed that the crude extract of P. guajava (water-alcohol extract obtained by macerating dry leaves) depresses the guinea pig atrial contractility in a concentration-dependent fashion (N = 8 hearts, 15 trials). The compound with cardiac activity was concentrated by extraction in a Soxhlet apparatus using 17 M glacial acetic acid after removing the less polar fractions (hexane, chloroform, acetone, ethanol and methanol), suggesting that this compound is a highly polar substance. In the isolated guinea pig left atrium the acetic acid fraction (10-800 mg/l) of P. guajava 1) reversibly decreased myocardial force in a concentration-dependent fashion (EC 50 = 0.07g/l, N = 5 hearts, 9 trials, P<0.05), 2) increased the atrial relaxation time measured at 20% of the force amplitude up to 35% (91 ± 15 to 123 ± 30 ms, N = 3 hearts, 6 trials, P<0.05), 3) abolished the positive staircase effect (Bowditch phenomenon) in a concentrationdependent fashion suggesting a decrease of the cellular inward calcium current (N = 4 hearts, 8 trials, P<0.05), and 4) its inotropic effect was abolished by cholinergic receptor blockade with 1.5 mM atropine sulfate, indicating a cholinergic involvement in the mechanism of action of the extract (N = 7 hearts, 15 trials, P<0.05). The acetic acid extract was 20 times more potent than crude extract (EC 50 = 1.4 g/l). The results showed that extracts from P. guajava leaves depress myocardial inotropism.

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“…Guava leaves, roots and fruits have also been used for the prevention and treatment of diarrhea 7,8) and diabetes 9,10) as a folk medicine and reportedly had an antimutagenic eŠect. 11,12) In a preliminary experiment, we screened the antibacterial activities of many kinds of plants used as folk medicine in Okinawa, Japan. A high level of antibacterial activity was detected in guava leaves.…”

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Isolation of Antimicrobial Compounds from Guava (Psidium guajava L.) and their Structural Elucidation

Arima

Danno

2002

Bioscience, Biotechnology, and Biochemistry

218

134

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Four antibacterial compounds were isolated from leaves of guava ( Psidium guajava L.), and the structures of these compounds were established on the basis of chemical and spectroscopic evidence. Two new ‰avo-noid glycosides, morin-3-O-a-L-lyxopyranoside and morin-3-O-a-L-arabopyranoside, and two known ‰avo-noids, guaijavarin and quercetin, were identiˆed. The minimum inhibition concentration of morin-3-O-a-Llyxopyranoside and morin-3-O-a-L-arabopyranoside was 200 mg W ml for each against Salmonella enteritidis, and 250 mg W ml and 300 mg W ml against Bacillus cereus, respectively.

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Studies on antimutagenic effects of guava (Psidium guajava) in Salmonella typhimurium

Cited by 59 publications

References 3 publications

Antiplasmodial activity of certain medicinal plants against chloroquine resistant Plasmodium berghei infected white albino BALB/c mice

Antiplasmodial activity of certain medicinal plants against chloroquine resistant Plasmodium berghei infected white albino BALB/c mice

Inotropic effects of extracts of Psidium guajava L. (guava) leaves on the guinea pig atrium

Isolation of Antimicrobial Compounds from Guava (Psidium guajava L.) and their Structural Elucidation

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