Studies on Antinephritic Effects of Plant Components (3): Effect of Pachyman, a Main Component of Poria Cocos Wolf on Original-Type Anti-GBM Nephritis in Rats and Its Mechanisms

Abstract

ABSTRACT-The antinephritic effect of pachyman on original-type anti-GBM nephritis in rats was in vestigated. Pachyman was given to original-type anti-GBM nephritic rats for 10 days from the day of anti-GBM serum injection. Pachyman prevented urinary protein excretion and the elevation of serum cholesterol content. Histopathological observations of the glomeruli indicated that although the number of nuclei and adhesion to capillary walls of Bowman's capsule in nephritic control rats were significantly increased, pachyman reduced the degree of histopathological changes such as hypercellularity and adhe sion as compared to the control group. Although the serum complement CH5() ratio in control group was significantly lower than that in the normal group, the decrease in serum complement CH5o was in hibited by pachyman, and rat C3 deposition in the glomeruli in the pachyman-treated group was signifi cantly reduced. These results suggest that pachyman was effective against original-type anti-GBM nephritis in rats and that the antinephritic mechanisms of pachyman may be partly due to the inhibitory action of this agent on C3 deposition in the glomeruli.

Acteoside, a Component of Stachys Sieboldii MIQ, May Be a Promising Antinephritic Agent: Effect of Acteoside on Crescentic-Type Anti-GBM Nephritis in Rats.

“…We previously reported that mizoribin and Aza, an im munosuppressive agent (7), inhibited the elevation of plas ma antibody against rabbit IgG and Pachyman, a main component of Poria cocos (18), decreased the degree of C3 deposition on the GBM, and both were markedly effec tive against anti-GBM nephritis.…”

“…7) Original-type anti-GBM nephritis was induced in rats by injection of 0.6 ml of anti-GBM serum into their tail veins, as described previously (18). Nephritic rats were pretreated and posttreated with ACT at 30 mg/kg, p.o.…”

A Phase II Study of an Herbal Decoction That Includes Astragali Radix for Cancer-Associated Anorexia in Patients With Advanced Cancer

“…31 Hoelen, Citri Unshiu Pericarpium, Agastachis Herba, Spatholobi Caulis, Rhynchosia Nulubilis and Glycyrrhizae Radix have anti-inflammatory activity as immune modulators. [35][36][37][38][39][40] Hoelen blocks selective serotonin reuptake inhibitors (SSRIs), which can induce anorexia with serotonin, and Pinelliae inhibits the vomiting center in animal models. 43,44 Appetite, body weight, and survival are endpoints for anorexia management in clinical trials.…”

“…The current herbal decoction, which includes Astragali Radix, [31][32][33][34] Atractylodis Rhizoma Alba, Hoelen, [35][36][37][38] Pinelliae Tuber, Citri Unshiu Pericarpium, 39 Agastachis Herba, 40 Alismatis Rhizoma, Plantaginis Semen, 41 Spatholobi Caulis, 42 Zizyphi Fructus, Rhynchosia Nulubilis, Crataegi Fructus, Galli Stomachichum Corium, and Glycyrrhizae Radix, is an immune modulator, is renoprotective, reduces lactate dehydrogenase, and increases gastrointestinal function. [43][44][45][46] This mixture has been developed to improve gastrointestinal function and modulate the immune system to treat anorexia.…”

Treatment Effect of ‘Ryu-Wei-Ti-Huang-Wan’ (a Chinese Herbal Prescription) on the Sexual Performance of Male Rats with Streptozotocin-lnduced Diabetes

“…Other therapeutic effects include promotion of reticulo-endothelial activity, anticomplementary action and improve ment of immune functions [21][22][23]. The other component Pori a cocos has been shown to suppress tumor necrosis factor a, interleukin 1(5, interleukin 6 and granulocytemonocyte colony-stimulating factor secretion from hu man monocytes [24], The extract also exhibited antinephritic effects [25], Paeonia suffruticosa, on the other hand, demonstrated radical scavenging and anti-oxida tive effects [26],…”