Treatment Effect of ‘Ryu-Wei-Ti-Huang-Wan’ (a Chinese Herbal Prescription) on the Sexual Performance of Male Rats with Streptozotocin-lnduced Diabetes

Abstract

The treatment effect of ‘ryu-wei-ti-huang-wan’, a Chinese prescription composed of extracts from six plants, on diabetic impotence was evaluated in the present study. Adult male Wistar rats were divided into three groups: (1) rats rendered diabetic with a single intraperitoneal injection of streptozotocin (60 mg/kg body weight); (2) rats with streptozotocin-induced diabetes treated with a ryu-wei-ti-huang-wan powder preparation at a dose of 30 mg powder/kg body weight twice a day, and (3) control rats. A male rat was caged with an adult ovariectomized female rat during the dark cycle. Infra-red-light-illuminated video recording was utilized to evaluate the sexual performance. The diabetic rats exhibited depressed mounting activity and no intromission or ejaculation. After ryu-wei-ti-huang-wan treatment either for 1 day or 2 weeks, the diabetic rats showed significant improvement in mounting performance with preservation of intromission and ejaculation. No significant difference in the blood sugar level was noted between the treatment and non-treatment groups. In conclusion, the diabetic rats showed impairment in sexual arousal, erectile as well as ejaculatory functions. Ryu-wei-ti-huang-wan was effective in preserving these functions with a rapid onset. It is evident that the extracts exert the therapeutic effects not through a lowering of blood sugar. These substances are potentially useful in the clinical treatment of male diabetic impotence.

Effects of Losartan on the Sexual Behavior of Male Rats

“…In our experiment, the level of libido of an animal could be inferred from the mount latency, mount frequency and PEP, whereas the erectile function was inferred from the intromission latency, intromission frequency and hit rate. The ejaculation latency was a measure of the ejaculatory function [22,24]. Thus after treatment with propranolol for 30 days, the SHR showed deterioration in libido and erectile function as well as ejaculatory function.…”

“…To evaluate the male sexual activities of the rats, the copulatory test would be started 60 min after giving the 7th, 30th, and 90th doses of drugs or saline of intromission divided by the number of mounts with or without intromission) as described in our previous reports [22,24].…”

Yukmijihwang-tang ameliorates ischemia/reperfusion-induced renal injury in rats

“…YJT is a decoction that consists of six medicinal plants, which are Rehmannia glutinosa, Alosma canaliculatum, Cornus officinalis sieb, Paeonia suffiruticosa, Poris cocos, and Dioscorea batatas. There have been many reports in the pharmacological efficacy of YJT with preventive and curative effects on tumors (Cai and Jiang, 1994), renal hypertension (Yi et al, 1965), diabetic impotence (Tong et al, 1996), asthma (Shen et al, 2003), and oxidative damages (Kim et al, 2000a).…”

Alternative Therapies for Male and Female Sexual Dysfunction

“…After ryu-wei-ti-huang-wan treatment either for 1 day or 2 weeks, the diabetic rats showed significant improvement in mounting performance with preservation of intromission and ejaculation. No significant difference in the blood sugar level was noted between the treatment and non-treatment groups (Tong et al, 1996).…”

“…Ryu-wei-ti-huang-wan is a Chinese herbal formulation composed of extracts from six plants (Tong et al, 1996). It was used in clinical treatment of male diabetic impotence.…”