Studies on antitussive principles of Asiasari radix.

Kosuge, Takuo; Yokota, Masami; Nukaya, Haruo; Gotoh, Yasuhisa; Nagasawa, Michio

doi:10.1248/cpb.26.2284

Cited by 42 publications

(21 citation statements)

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“…Blood samples (1mL) were withdrawn from the right ear vein through a catheter after 1,3,5,7,9,12,15,20,30,40,60,80,100,120,121,123,125,127,129,132,135,140,150,165,180, and 210min. The plasma samples were treated as described for IV administration.…”

Section: Administration Of Higenamine To Rabbits By Constant Zv Infusionmentioning

confidence: 99%

Pharmacokinetics of Higenamine in Rabbits

Chen

1996

Biopharm. Drug Dispos.

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Section: Administration Of Higenamine To Rabbits By Constant Zv Infusionmentioning

confidence: 99%

Pharmacokinetics of Higenamine in Rabbits

Chen

1996

Biopharm. Drug Dispos.

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“…According to the previous results, it could be concluded that non-volatile constituents existed in AR also had the anti-inflammatory and analgesic activities. However, although AR worked to control pain and inflammation in traditional Chinese medicine prescriptions, there was not enough research to explain its non-volatile active components of analgesia and anti-inflammation, in spite of a few previous papers reporting its potential anti-tussive, anti-tumor, and anti-inflammatory effects [5,6,22,23], along with anti-allergic and anti-inflammatory components of Asiasarum sieboldi F. Maekawa belonging to the same genus [24,25,26]. …”

Section: Introductionmentioning

confidence: 99%

Chemical Constituents from the Roots and Rhizomes of Asarum heterotropoides var. mandshuricum and the In Vitro Anti-Inflammatory Activity

et al. 2017

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Anti-inflammatory compounds were investigated from the ethanol extract of the roots and rhizomes of Asarum heterotropoides var. mandshuricum, a traditional Chinese medicine called Xixin and used for pain and inflammatory. Nine new compounds were isolated, including six new lignans, neoasarinin A–C (1–3), neoasarininoside A and B (4 and 5), and asarinin B (7), and one new monoterpene, asarincin A (8), two new amides, asaramid II and III (10 and 11), and one new natural monoterpene, asaricin B (9), along with 37 known compounds (6, 12–47). Their structures and absolute configurations were elucidated on the basis of spectroscopic methods and chemical analyses. This is the first report of the absolute configuration of asarinin A (6). The 8-O-4′ neolignans (1–5) were reported in the genus Asarum for the first time. The 15 compounds 17, 19, 22–25, 28, 31, 36, 40, 42, 43, 45–47 were isolated from the genus Asarum, and compounds 16, 32, 33, 37 and 39 were isolated from A. heterotropoides var. mandshuricum for the first time. Thirty-seven of the isolates were evaluated for anti-inflammatory activity against the release of β-glucuronidase in polymorphonuclear leukocytes (PMNs) induced by the platelet-activating factor (PAF), and compounds 1, 4, 7, 8, 14, 17–19, 22, 24, 25, 29, 30, 32, 33, 40–43, 45, and 46 showed potent anti-inflammatory activities in vitro, with 27.9%–72.6% inhibitions at 10−5 mol/L. The results of anti-inflammatory assay suggested that lignans obtained from the CHCl3 extract might be the main active components of Xixin.

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“…Asiasari radix, which called saishin in Japanese or Chinese wild ginger in English, is prepared from Asiasarum sieboldii F. Maekawa or Asiasarum heterotropoides F. Maekawa var. mandshuricum F. Maekawa, and widely used for treatment of various tussive, inflammatory, and allergic diseases and pain (Kosuge et al, 1978;Koda et al, 1982). Japanese herbal medicines (known as "kampo medicines" in Japan) containing Asiasari radix have also been used as analgesic, antitussive, and anti-allergic therapies.…”

Section: Introductionmentioning

confidence: 99%