Studies on Bioavailability Enhancement of Curcumin

Abstract

Objective: The objective of the present work was to improve aqueous solubility and in vivo bioavailability of curcumin and structural analogues of curcumin such as potassium, calcium, magnesium salts and nitro derivative.
 Methods: Structural analogues of curcumin were prepared by reaction of curcumin with potassium chloride, magnesium chloride hexahydrate and calcium chloride dihydrate in a suitable solvent. The nitro derivative synthesized by treating curcumin with sulphuric acid and nitric acid. The prepared analogues were evaluated for melting behavior, solubility, UV spectrophotometry, partition coefficient, moisture content, cellular uptake, FTIR analysis, antimicrobial activity and in vivo bioavailability in the rat.
 Results: Chemical modification of curcumin increased the saturation solubility to 11.6, 16.5, 21.5, 28.0 µg/ml in calcium salt, magnesium salt, potassium salt and nitro derivative respectively, against 8.6 µg/ml of curcumin. The analogues were chemically stable as curcumin analyzed by FTIR spectrophotometry. Increased cellular uptake, as well as enhanced antimicrobial activity, was demonstrated by modified curcumin analogues. Moreover, significant improvement in plasma levels was estimated with nitro derivative.
 Conclusion: The present work recommends that nitration of curcumin improves aqueous solubility which may improve absorption and in vivo bioavailability.

A Review of Different Approaches for Improving Curcumin Bioavailability

“…Its chemical name is bis-alphaunsaturated -diketone, or diferuloylmethane. 2 Curcumin has a wide range of uses, including antibacterial activity 3 , anti-inflammatory 4 , anti-oxidant 5 , pro-apoptotic 6 , chemopreventive 7 , chemotherapeutic 5 , anti-proliferative 6,8 , wound healing, anti-nociceptive 9 , antiparasitic 10 , antimalarial 11 , diabetes 12 , obesity, neurologic, psychiatric disorders 13 , cancer 4 , and chronic illnesses affecting the eyes, lungs, liver, kidneys, gastrointestinal 14 , and reproductive system 15 and as nanotechnology advances, nanoparticles will become more significant in new drug delivery systems. Nanoparticle formulation will provide new ways to improve solubility, stability, bioavailability, pharmacological activity, and the ability to avoid physical and chemical degradation.…”

Boosting the Skin Delivery of Curcumin Through Stearic Acid-Ethyl Cellulose Blend Hybrid Nanocarriers-Based Approach for Mitigating Psoriasis

“…Curcumin is a yellow-colored polyphenolic compound obtained from the rhizome of the perennial herb Curcuma longa and possesses outstanding anticancer properties [19]. Despite the promising therapeutic value offered by curcumin, its translation from basic research to clinical application is limited due to poor water solubility and low bioavailability [20,21]. Therefore, the present study was engineered to develop and characterize the LPHNP based hydrogels for the topical delivery of curcumin and compares the in vivo anti-psoriatic efficacy with the commercial marketed product in hopes of assessing a relatively effective and safe medicine for the psoriasis treatment.…”