Studies on Cotton Seed Meal Toxicity. Ii

Withers, W. A.; Brewster, Joseph F.; Curtis, Robert Seth; Roberts, George A. F.; Williams, Louise; Nowell, J.W.

doi:10.1016/s0021-9258(18)88552-0

Cited by 35 publications

(4 citation statements)

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“…The feasibility of removing gossypol by solvent extraction also has been investigated (35,62,125). The addition of water-soluble iron salts to diets containing cottonseed meal reduces the danger of injury (77,86,88,146,188,225,231,234), and the inclusion of sodium bicarbonate and calcium carbonate in the diet of experimental animals has been reported (92,93,94) to lower the toxicity of the meal. For this reason, Gallup and Reder (93) suggested that in the biological assay of gossypol-containing substances, the diet should contain only the amount of calcium and sodium necessary for maintenance and moderate growth.…”

Section: Physiological Action Of Gossypolmentioning

confidence: 99%

Gossypol, a Pigment of Cottonseed.

Adams¹,

Geissman²,

Edwards³

1960

Chem. Rev.

264

124

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Section: Physiological Action Of Gossypolmentioning

confidence: 99%

Gossypol, a Pigment of Cottonseed.

Adams¹,

Geissman²,

Edwards³

1960

Chem. Rev.

264

124

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“…Iron was found to protect rabbits from gossypol toxicity when administered in the form of ferric ammonium citrate (Withers and Brewster, 1913). Iron has also been shown to be partially effective in preventing the accumulation of gossypol in porcine liver (Buitrago et al, 1970).…”

Section: Introductionmentioning

confidence: 99%

Cottonseed with a High (+)- to (−)-Gossypol Enantiomer Ratio Favorable to Broiler Production

Bailey

Stipanovic

Ziehr

et al. 2000

J. Agric. Food Chem.

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This study was designed to evaluate the relative toxicity of (+)- and (-)-gossypol enantiomers in 0-3-week-old broilers. Treatments consisted of broiler starter diets formulated with either a glandless, which did not contain gossypol, a commercial glanded [62. 2% (+)-gossypol], or a glanded moco [83.2% (+)-gossypol] crushed cottonseed (CCS) (six replicates/treatment) plus a soybean meal negative control. Glandless cottonseed was mixed with the moco cottonseed (2.4% free gossypol) so that both the commercial glanded and moco glanded cottonseeds contained equivalent concentrations of free gossypol (2.0%). The cottonseed treatments were added at 5 and 10% of the diet. Body weights and feed conversions were determined weekly. Body weights and feed-to-gain ratios of broilers fed 5 and 10% glandless CCS and 5% moco CCS were not significantly different. Broilers receiving 10% commercial glanded CCS weighed significantly less than those subjected to all other treatments. Feed-to-gain ratios were significantly higher for broilers receiving 10% commercial glanded and 10% moco CCS as compared to 5% moco and glandless CCS, 10% glandless CCS, and control. Relative liver weights of birds receiving 10% moco CCS were significantly less than those of birds receiving 10% commercial CCS. The data clearly showed that broilers fed moco CCS containing a relatively high (+)- to (-)-gossypol enantiomer ratio performed better than broilers receiving commercial CCS with a lower (+)- to (-)-gossypol enantiomer ratio.

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“…The data show reduced iron uptake by the intestinal mucosa, thus suggesting that the iron is more tightly bound in the ferrous-gossypol complex than those used physiologically for iron absorption. It has been shown, however, that nonruminant animals are protected against gossypol toxicity when a divalent iron salt is added to their diet (Withers and Brewster, 1913;Gallup, 1928;Olcott, 1948;Eagle, 1949; Clawson and Smith, 1966;Smith and Clawson, 1970). Some complexes of iron are poorly absorbed by the intestinal mucosa (Benjamin et al, 1967;Somers, 1947;Moore, 1961).…”

Section: Discussionmentioning

confidence: 99%