Studies on DNA Interaction with 2(3),9(10), 16(17), 23(24)‐Tetrakis 2((4‐Phenoxyphenyl) Diazeylbenzoic acid)phthalocyaninato Zinc (II) Compound

Abstract

In this study, 2(3), 9(10), 16(17), 23(24)‐tetrakis 2((4‐phenoxyphenyl) diazeylbenzoic acid)phthalocyaninato zinc (II) compound was chosen to study DNA binding activities. The binding activities of zinc (II) phthalocyanine compound bearing 2(3),9(10), 16(17), 23(24)‐tetrakis 2((4‐Phenoxyphenyl) diazeylbenzoic acid) ligand with Calf Thymus (CT)‐DNA was investigated using absorption titration, fluorescence spectroscopy, cyclic voltammetry and thermal melting profile in a Tris‐HCl buffer system at pH 7.0. In addition to these methods, gel electrophoresis and viscosity measurements were also carried out to determine DNA binding activities with compound 6 in a buffer solution. The results indicated that compound 6 interacts with CT‐DNA through partial intercalation binding mode.

Synthesis and Characterization of Ni(II)/Zn(II) Metal Complexes Derived from Schiff Base and Ortho‐Phenylenediamine: In vitro DNA Binding, Molecular Modeling and RBC Hemolysis

“…It is observed that ΔT m value of 4–6 °C for complexes 1 and 2 was much larger than ΔT m < 2 °C for electrostatic DNA binder [Ru(bpy) 3 ] 2+ , but lower than that of traditional intercalator ethidium bromide (EB) with ΔT m of 13 °C . These results suggested groove binding interaction along with partial intercalative behavior of complexes 1 and 2 inside the DNA helix in conformity with electronic absorption spectra and viscosity studies …”

DNA binding studies of the 2,10,16,24–tetrakis (phenoxy-3-methoxybenzoic acid)phthalocyaninato) Co(II) and Cu(II) compounds

“…The gel electrophoresis experiments were recorded at 80 V during 3 h in the buffer solution (TBE) and the bands of the DNA were photographed using a BioRad system. In this method, the measurements were carried out with a Thermo Scientific gel electrophoresis system [29][30][31][32].…”